Russian Journal of Organic Chemistry

, Volume 52, Issue 7, pp 970–973 | Cite as

Three-component synthesis of methyl 6-alkyl-3-cyano-2-halopyridine-4-carboxylates

Article

Abstract

A procedure has been developed for the synthesis of methyl 6-alkyl-3-cyano-2-halopyridine-4-carboxylate by three-component reaction of 4-oxoalkane-1,1,2,2-tetracarbonitriles with hydrogen halides in methanol.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Tsarichenko, G.V., Bobrov, V.I., and Starkov, M.V., Pharm. Chem. J., 1977, vol. 11, p. 481.CrossRefGoogle Scholar
  2. 2.
    Suarez, J., Ranguelova, K., and Jarzecki, A.A., J. Biol. Chem., 2009, vol. 284, p. 7017.CrossRefGoogle Scholar
  3. 3.
    Ershov, O.V., Fedoseev, S.V., Belikov, M.Yu., and Ievlev, M.Yu., RSC Adv., 2015, vol. 5, p. 34 191.CrossRefGoogle Scholar
  4. 4.
    Ershov, O.V., Lipin, K.V., Maksimova, V.N., Eremkin, A.V., Kayukov, Ya.S., and Nasakin, O.E., Russ. J. Org. Chem., 2009, vol. 45, p. 475.CrossRefGoogle Scholar
  5. 5.
    Ershov, O.V., Maksimova, V.N., Lipin, K.V., Belikov, M.Y., Ievlev, M.Y., Tafeenko, V.A., and Nasakin, O.E., Tetrahedron, 2015, vol. 71, no. 39, 7445.CrossRefGoogle Scholar
  6. 6.
    Eremkin, A.V., Molkov, S.N., Ershov, O.V., Kayukov, Y.S., Nasakin, O.E., Tafeenko, V.A., and Nurieva, E.V., Mendeleev Commun., 2006, vol. 16, no. 2, p. 115.CrossRefGoogle Scholar
  7. 7.
    Yashkanova, O.V., Lukin, P.M, Nasakin, O.E., Urman, Ya.G., Khrustalev, V.N., Nesterov, V.N., Antipin, M.Yu., and Vershinin, E.V., Russ. J. Org. Chem., 1997, vol. 33, p. 484.Google Scholar
  8. 8.
    Bardasov, I.N., Alekseeva, A.U., Mihailov, D.L., Ershov, O.V., Nasakin, O.E., and Tafeenko, V.A., Tetrahedron Lett., 2014, vol. 55, p. 2730.CrossRefGoogle Scholar
  9. 9.
    Fedoseev, S.V., Ershov, O.V., Belikov, M.Yu., Lipin, K.V., Bardasov, I.N., Nasakin, O.E., and Tafeenko, V.A., Tetrahedron Lett., 2013, vol. 54, p. 2143.CrossRefGoogle Scholar
  10. 10.
    Yoshida, K. and Otomasu, H., Yakugaku Zasshi, 1976, vol. 96, no. 1, p. 33.Google Scholar
  11. 11.
    Havas, F., Leygue, N., Danel, M., Mestre, B., Galaup, C., and Picard, C., Tetrahedron, 2009, vol. 55, no. 36, p. 7673.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.I.N. Ul’yanov Chuvash State UniversityCheboksaryRussia

Personalised recommendations