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Efficient one-stage procedure of Beckmann ketones rearrangement in the presence of hydroxylamine

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Abstract

Ketoximes formed from ketones in the presence of hydroxylamine and silica gel in formic acid undergo in situ the Beckmann rearrangement under mild conditions affording in high yields the corresponding amides. Unsymmetrical aromatic ketones, methyl aryl ketones, and methyl cyclohexyl ketone under these conditions form as a rule amides mixtures.

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Correspondence to V. Yu. Kuksenok.

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Original Russian Text © V.Yu. Kuksenok, V.V. Shtrykova, V.D. Filimonov, S.P. Sidel’nikova, 2016, published in Zhurnal Organicheskoi Khimii, 2016, Vol. 52, No. 2, pp. 214–216.

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Kuksenok, V.Y., Shtrykova, V.V., Filimonov, V.D. et al. Efficient one-stage procedure of Beckmann ketones rearrangement in the presence of hydroxylamine. Russ J Org Chem 52, 196–199 (2016). https://doi.org/10.1134/S1070428016020056

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  • DOI: https://doi.org/10.1134/S1070428016020056

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