Russian Journal of Organic Chemistry

, Volume 52, Issue 1, pp 76–79 | Cite as

N-(4-methoxy-3-nitrobenzyl) derivatives of some nitrogen-containing heterocycles



A number of nitrogen heterocycles reacted with 4-methoxy-3-nitrobenzyl chloride in dimethyl-formamide in the presence of potassium carbonate to give the corresponding N-(4-methoxy-3-nitrobenzyl) derivatives. The reaction of 5-fluoro-1,3-bis(4-methoxy-3-nitrobenzyl)pyrimidine-2,4(1H,3H)-dione with aqueous methylamine afforded N,N′-bis(4-methylamino-3-nitrobenzyl)urea, whereas analogous reaction with 1-(4-methoxy-3-nitrobenzyl)-2-(methylsulfanyl)-1H-benzimidazole resulted in substitution of the methoxy group by methylamino.


Isatin Potassium Carbonate Methylamino Benzyl Chloride Methylsulfanyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.Mndzhoyan Institute of Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical ChemistryNational Academy of Sciences of ArmeniaYerevanArmenia

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