Russian Journal of Organic Chemistry

, Volume 52, Issue 1, pp 76–79 | Cite as

N-(4-methoxy-3-nitrobenzyl) derivatives of some nitrogen-containing heterocycles

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Abstract

A number of nitrogen heterocycles reacted with 4-methoxy-3-nitrobenzyl chloride in dimethyl-formamide in the presence of potassium carbonate to give the corresponding N-(4-methoxy-3-nitrobenzyl) derivatives. The reaction of 5-fluoro-1,3-bis(4-methoxy-3-nitrobenzyl)pyrimidine-2,4(1H,3H)-dione with aqueous methylamine afforded N,N′-bis(4-methylamino-3-nitrobenzyl)urea, whereas analogous reaction with 1-(4-methoxy-3-nitrobenzyl)-2-(methylsulfanyl)-1H-benzimidazole resulted in substitution of the methoxy group by methylamino.

Keywords

Isatin Potassium Carbonate Methylamino Benzyl Chloride Methylsulfanyl 

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.Mndzhoyan Institute of Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical ChemistryNational Academy of Sciences of ArmeniaYerevanArmenia

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