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C- and O-alkylation of ecdysteroids in lithium-ammonia solution

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Abstract

Reactions of ecdysteroids with alkyl halides in lithium-ammonia solution stereospecifically led to the formation of 7α-alkylated 14-deoxy-Δ8(14)-ecdysteroids. In the presence in the initial compound of free secondary hydroxy groups in the positions 2, 3, or 22 in some cases a side process of О-alkylation as well occurred.

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Authors and Affiliations

  1. Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, pr. Oktyabrya 141, Ufa, 450075, Bashkortostan, Russia

    I. V. Galyautdinov, Z. R. Khairullina, O. S. Mozgovoi, L. M. Khalilov, Z. S. Muslimov & V. N. Odinokov

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  1. I. V. Galyautdinov
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  2. Z. R. Khairullina
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  3. O. S. Mozgovoi
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  4. L. M. Khalilov
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  5. Z. S. Muslimov
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  6. V. N. Odinokov
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Corresponding author

Correspondence to I. V. Galyautdinov.

Additional information

Original Russian Text © I.V. Galyautdinov, Z.R. Khairullina, O.S. Mozgovoi, L.M. Khalilov, Z.S. Muslimov, V.N. Odinokov, 2015, published in Zhurnal Organicheskoi Khimii, 2015, Vol. 51, No. 11, pp. 1662–1670.

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Galyautdinov, I.V., Khairullina, Z.R., Mozgovoi, O.S. et al. C- and O-alkylation of ecdysteroids in lithium-ammonia solution. Russ J Org Chem 51, 1633–1641 (2015). https://doi.org/10.1134/S1070428015110196

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  • DOI: https://doi.org/10.1134/S1070428015110196

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