Russian Journal of Organic Chemistry

, Volume 51, Issue 5, pp 705–710 | Cite as

Synthesis and properties of derivatives of pyrimidin-5-ylpropanoic acids and 8-aryl-4-methyl- and 4,6-dimethyl-2-phenyl-5,6,7,8-tetrahydropyrido-[2,3-d]pyrimidin-7-ones

  • A. A. Harutyunyan
  • G. A. Panosyan
  • S. G. Chishmarityan
  • R. V. Paronikyan
  • H. M. Stepanyan
Article
  • 45 Downloads

Abstract

Proceeding from 3-(4-methyl-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinyl)propanoic and 2-methylpropanoic acids by successive reactions of chlorination, amination, and heterocyclization 4-amino-substituted pyrimidines were synthesized: 5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives and 4-methyl-2-phenyl-5,6-dihydrobenzo[4′,5′]imidazo[2′,1′:6,1]pyrido[2,3-d]pyrimidine which we had previously obtained by alternative method. Antibacterial properties of the synthesized compounds were studied.

Keywords

Pyrimidine Propanoic Acid Isobutyl Alcohol Propanamide Rimidines 

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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • A. A. Harutyunyan
    • 1
  • G. A. Panosyan
    • 2
  • S. G. Chishmarityan
    • 2
  • R. V. Paronikyan
    • 1
  • H. M. Stepanyan
    • 1
  1. 1.Scientific and Technologic Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of ArmeniaMnjoyan Institute of Fine Organic ChemistryYerevanArmenia
  2. 2.Center of Study of Molecular StructureNational Academy of Sciences of ArmeniaYerevanArmenia

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