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Polyfunctional imidazoles: IX. Synthesis of 1-aryl-5-(2-aryl-3,4-dihydro-2H-pyrrol-4-yl)-4-chloro-1H-imidazoles

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Abstract

1-Aryl-3-(1-aryl-4-chloro-1H-imidazol-5-yl)prop-2-en-1-ones prepared from 1-aryl-4-chloro-1H-imidazole-5-carbaldehydes and methyl aryl ketones reacted with nitromethane affording 1-aryl-3-(1-aryl-4-chloro-1H-imidazol-5-yl)-4-nitrobutan-1-ones which were reduced with zink in acetic acid to obtain 1-aryl-5-(2-aryl-3,4-dihydro-2H-pyrrol-4-yl)-4-chloro-1H-imidazoles.

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Author information

Authors and Affiliations

  1. Ivano-Frankovsk National Medical University, Ivano-Frankovsk, Ukraine

    O. Ya. Mel’nik

  2. Bukovina State Medical University, Chernovtsy, Ukraine

    V. A. Chornous

  3. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, ul. Murmanskaya 5, Kiev, 02094, Ukraine

    M. V. Vovk

Authors
  1. O. Ya. Mel’nik
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  2. V. A. Chornous
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  3. M. V. Vovk
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Corresponding author

Correspondence to M. V. Vovk.

Additional information

Original Russian Text © O.Ya. Mel’nik, V.A. Chornous, M.V. Vovk, 2015, published in Zhurnal Organicheskoi Khimii, 2015, Vol. 51, No. 2, pp. 250–254.

For communication VIII, see [1].

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Mel’nik, O.Y., Chornous, V.A. & Vovk, M.V. Polyfunctional imidazoles: IX. Synthesis of 1-aryl-5-(2-aryl-3,4-dihydro-2H-pyrrol-4-yl)-4-chloro-1H-imidazoles. Russ J Org Chem 51, 240–244 (2015). https://doi.org/10.1134/S1070428015020189

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  • DOI: https://doi.org/10.1134/S1070428015020189

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