Russian Journal of Organic Chemistry

, Volume 51, Issue 2, pp 240–244 | Cite as

Polyfunctional imidazoles: IX. Synthesis of 1-aryl-5-(2-aryl-3,4-dihydro-2H-pyrrol-4-yl)-4-chloro-1H-imidazoles

  • O. Ya. Mel’nik
  • V. A. Chornous
  • M. V. Vovk


1-Aryl-3-(1-aryl-4-chloro-1H-imidazol-5-yl)prop-2-en-1-ones prepared from 1-aryl-4-chloro-1H-imidazole-5-carbaldehydes and methyl aryl ketones reacted with nitromethane affording 1-aryl-3-(1-aryl-4-chloro-1H-imidazol-5-yl)-4-nitrobutan-1-ones which were reduced with zink in acetic acid to obtain 1-aryl-5-(2-aryl-3,4-dihydro-2H-pyrrol-4-yl)-4-chloro-1H-imidazoles.


Imidazole Pyrrole Nitromethane Zinc Powder Reductive Cyclization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • O. Ya. Mel’nik
    • 1
  • V. A. Chornous
    • 2
  • M. V. Vovk
    • 3
  1. 1.Ivano-Frankovsk National Medical UniversityIvano-FrankovskUkraine
  2. 2.Bukovina State Medical UniversityChernovtsyUkraine
  3. 3.Institute of Organic ChemistryNational Academy of Sciences of UkraineKievUkraine

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