Russian Journal of Organic Chemistry

, Volume 51, Issue 1, pp 54–64 | Cite as

Ammonium chloride-catalyzed four-component sonochemical synthesis of novel hexahydroquinolines bearing a sulfonamide moiety

Article

Abstract

Ammonium chloride as a very inexpensive and readily available reagent efficiently catalyzes one-pot four-component condensation of dimedone with aromatic aldehyde, malononitrile or ethyl cyanoacetate, and sulfonamide derivatives in ethanol at 70°C under ultrasonic irradiation to afford the corresponding 2-amino-4-aryl-1,4,5,6,7,8-hexahydroquinolines bearing a sulfonamide moiety in high yields. In comparison to conventional methods, high yields, easy work-up, and short reaction time are advantages of this sonochemical procedure. The effects of the catalyst, solvent, and temperature are assessed.

Keywords

Ammonium Chloride Aromatic Aldehyde Short Reaction Time Malononitrile Ultrasonic Irradiation 

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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of ScienceAssiut UniversityAssiutEgypt
  2. 2.Department of Chemistry, Faculty of Applied SciencesUmm Al-Qura UniversityMakkahSaudi Arabia

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