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5-Amino-N-(2,2-dialkoxyethyl)pyrazole-4-carboxamides in the synthesis of 7-sulfanyl-5,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]diazepin-4-ones

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Abstract

5-Amino-N-(2,2-dialkoxyethyl)pyrazole-4-carboxamides obtained by hydrolytic cleavage of 5-(2,2-diethoxyethyl)pyrazolo[3,4-d]pyrimidin-4-ones or by condensation of 3-(dimethylamino)-N-(2,2-dimethoxyethyl)-2-cyanoacrylamides with alkylhydrazines in formic acid react with benzylthiol or thiophenols to afford 7-benzyl(aryl)sulfanyl-5,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]diazepin-4-ones.

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Authors and Affiliations

  1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanskaya ul. 5, Kiev, 02660, Ukraine

    A. V. Bol’but, S. V. Kemskii & M. V. Vovk

Authors
  1. A. V. Bol’but
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  2. S. V. Kemskii
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  3. M. V. Vovk
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Corresponding author

Correspondence to M. V. Vovk.

Additional information

Original Russian Text © A.V. Bol’but, S.V. Kemskii, M.V. Vovk, 2014, published in Zhurnal Organicheskoi Khimii, 2014, Vol. 50, No. 5, pp. 697–702.

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Bol’but, A.V., Kemskii, S.V. & Vovk, M.V. 5-Amino-N-(2,2-dialkoxyethyl)pyrazole-4-carboxamides in the synthesis of 7-sulfanyl-5,6,7,8-tetrahydro-1H-pyrazolo[3,4-e][1,4]diazepin-4-ones. Russ J Org Chem 50, 685–690 (2014). https://doi.org/10.1134/S107042801405011X

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  • DOI: https://doi.org/10.1134/S107042801405011X

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