Russian Journal of Organic Chemistry

, Volume 50, Issue 4, pp 513–517 | Cite as

Synthesis of 1′-substituted 4′,4′-dimethyl-6′-methoxy-4′H-spiro[cyclohexane-1,3′-isoquinolines]

  • A. N. Perevoshchikova
  • A. A. Gorbunov
  • Yu. S. Rozhkova
  • P. A. Slepukhin
  • Yu. V. Shklyaev
Article
  • 69 Downloads

Abstract

The reaction of 1-(4-methoxyphenyl)-1-(1-methylcyclohexyl)ethanol with nitriles in concentrated sulfuric acid afforded 1′-substituted 6′-methoxy-4′,4′-dimethyl-4′H-spiro[cyclohexane-1,3′-isoquinolines] as a result of consecutive Wagner-Meerwein rearrangement and Ritter reaction.

Keywords

Methanone Methylsulfanyl Dihydroisoquinoline Yellow Oily Substance Ritter Reaction 

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Copyright information

© Pleiades Publishing, Ltd. 2014

Authors and Affiliations

  • A. N. Perevoshchikova
    • 1
  • A. A. Gorbunov
    • 1
  • Yu. S. Rozhkova
    • 1
  • P. A. Slepukhin
    • 2
  • Yu. V. Shklyaev
    • 1
  1. 1.Institute of Technical Chemistry, Ural BranchRussian Academy of SciencesPermRussia
  2. 2.Postovskii Institute of Organic Synthesis, Ural BranchRussian Academy of SciencesYekaterinburgRussia

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