Russian Journal of Organic Chemistry

, Volume 49, Issue 11, pp 1610–1616 | Cite as

Synthesis and application of chalcones to the preparation of heterocyclic structures

  • A. V. Velikorodov
  • V. A. Ionova
  • S. I. Temirbulatova
  • O. L. Titova
  • N. N. Stepkina
Article

Abstract

Condensation of methyl N-(4-acetylphenyl)carbamate with aromatic aldehydes in basic and acid environment, and also with hetarylaldehydes in the presence of bases afforded chalcones with the carbamate function. Under the conditions of basic catalysis a nucleophilic substitution was observed of a methoxy group in the carbamate moiety of the chalcone for an ethoxy group. The reactions of the obtained chalcones with hydrazine hydrate, isonicotinic acid hydrazide, guanidine and hydroxylamine hydrochlorides, thiourea, and selenium dioxide furnished the corresponding derivatives of pyrazole, oxazole, pyrimidine, and selenadiazole.

Keywords

Furfural Carbamate Chalcone Hydrazine Hydrate Light Yellow Crystal 

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Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  • A. V. Velikorodov
    • 1
  • V. A. Ionova
    • 1
  • S. I. Temirbulatova
    • 1
  • O. L. Titova
    • 1
  • N. N. Stepkina
    • 1
  1. 1.Astrakhan State UniversityAstrakhanRussia

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