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Russian Journal of Organic Chemistry

, Volume 49, Issue 4, pp 516–525 | Cite as

2-chloro-3,3,5-trimethyl-2,3-dihydro-1,2λ5-oxaphosphole 2-oxide as precursor in a new synthesis of dialkyl(diaryl)-(2-methyl-4-oxopent-2-yl)phosphine oxides

  • D. A. Tatarinov
  • A. A. Kostin
  • T. A. Baronova
  • A. B. Dobrynin
  • E. V. Mironova
  • D. B. Krivolapov
  • B. I. Buzykin
  • V. F. Mironov
Article

Abstract

A new approach has been developed to the synthesis of dialkyl(diaryl)(2-methyl-4-oxopent-2-yl)-phosphine oxides that are structural analogs of the drug dimephosphon. This approach is based on the reaction of 2-chloro-3,3,5-trimethyl-3H-1,2λ5-oxaphosphole 2-oxide with Grignard compounds, and it ensures high yields of the target products. The structure of bis(2-methoxyphenyl)(2-methyl-4-oxopent-2-yl)phosphine oxide was determined by X-ray analysis. (2-Methyl-4-oxopent-2-yl)dipropylphosphine oxide with magnesium bromide formed a 4: 1 complex whose structure was also determined by X-ray analysis.

Keywords

Phosphine Oxide Mesityl Oxide Magnesium Bromide White Crystalline Powder Diphenylphosphine Oxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  • D. A. Tatarinov
    • 1
  • A. A. Kostin
    • 1
  • T. A. Baronova
    • 1
  • A. B. Dobrynin
    • 1
  • E. V. Mironova
    • 1
  • D. B. Krivolapov
    • 1
  • B. I. Buzykin
    • 1
  • V. F. Mironov
    • 1
  1. 1.Arbuzov Institute of Organic and Physical Chemistry, Kazan Research CenterRussian Academy of SciencesKazanTatarstan, Russia

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