Russian Journal of Organic Chemistry

, Volume 48, Issue 10, pp 1323–1325 | Cite as

Reduction and hydrolysis of substituted 5-oxa-6-azaspiro[2.4]heptane-1,2-dicarboxylic acid esters

Article

Abstract

Substituted 5-oxa-6-azaspiro[2.4]heptane-1,2-dicarboxylic acid esters synthesized by reaction of nitrones with dimethyl 3-methylidenecyclopropane-1,2-dicarboxylate were reduced with lithium tetrahydridoaluminate to the corresponding bis(hydroxymethyl)cyclopropanes. Alkaline hydrolysis of the title compounds gave substituted cyclopropane-1,2-dicarboxylic acids. In both cases, the 5-oxa-6-azaspiro[2.4]heptane fragment remained intact.

Keywords

Dicarboxylic Acid Alkaline Hydrolysis Nitrones Cyclopropane Ring Isoxazolidine 

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  1. 1.St. Petersburg State UniversitySt. PetersburgRussia

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