Russian Journal of Organic Chemistry

, Volume 48, Issue 10, pp 1289–1296 | Cite as

Synthesis of acetals containing a primary amino group

  • N. A. Lobanova
  • V. K. Stankevich
  • B. F. Kukharev
Article

Abstract

Amino acetals of the general formula MeCH(OR)(OXNH2) (R = Et, Bu, X = CH2CH2, CH2CH2CH2, CH2CMe2) were synthesized in 53–91% yield by acid-catalyzed reaction of N-(2-hydroxyethyl)-, N-(3-hydroxypropyl)-, and N-(2-hydroxy-1,1-dimethylethyl)-2,2,2-trifluoroacetamides with vinyl ethers, followed by removal of the trifluoroacetyl protection by alkaline hydrolysis.

Keywords

Vinyl Ether Amino Alcohol Vinyloxy Ethanamine Ketone Diethyl 

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • N. A. Lobanova
    • 1
  • V. K. Stankevich
    • 1
  • B. F. Kukharev
    • 1
  1. 1.Favorskii Irkutsk Institute of Chemistry, Siberian DivisionRussian Academy of SciencesIrkutskRussia

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