Russian Journal of Organic Chemistry

, Volume 48, Issue 8, pp 1121–1125 | Cite as

Synthesis of maleopimaric and citraconopimaric acids N-[3-(pyrimidin-2-yl)aryl]amides

  • E. V. Koroleva
  • K. N. Gusak
  • Zh. V. Ignatovich
  • A. L. Ermolinskaya
  • M. P. Bei
  • A. P. Yuvchenko
Article

Abstract

Acylation of 6-methyl-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine, 4-methyl-N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine, and N-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine with maleopimaric and citraconopimaric acid chlorides, with benzotriazolyl maleopimarate afforded N-[3-(pyrimidin-2-yl)aryl]amides of maleopimaric and citraconopimaric acids. By the reaction of substituted N-arylamides of maleopimaric acid with methanesulfonic acid biologically active methanesulfonates were obtained.

Keywords

Imatinib Chronic Myeloid Leukemia Colorless Crystal Nilotinib Thionyl Chloride 

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • E. V. Koroleva
    • 1
  • K. N. Gusak
    • 1
  • Zh. V. Ignatovich
    • 1
  • A. L. Ermolinskaya
    • 1
  • M. P. Bei
    • 1
  • A. P. Yuvchenko
    • 1
  1. 1.Institute of New Materials Chemistry of National Academy of BelarusAcademy of Sciences of BelarusMinskBelarus’

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