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Regioselective reaction of 5,6-dialkyl-2-halopyridine-3,4-dicarbonitriles with ammonia

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Abstract

The reaction of 5,6-dialkyl-2-halopyridine-3,4-dicarbonitriles with alcoholic ammonia under elevated pressure gave 5,6-dialkyl-2-aminopyridine-3,4-dicarbonitriles as a result of nucleophilic replacement of the halogen atom by amino group. 6,7-Dialkyl-4-halo-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diimines were formed in analogous reaction at room temperature in the presence of potassium carbonate.

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Authors and Affiliations

  1. I.N. Ul’yanov Chuvash State University, Moskovskii pr. 15, Cheboksary, 428015, Russia

    V. N. Maksimova, O. V. Ershov, K. V. Lipin, A. V. Eremkin & O. E. Nasakin

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  1. V. N. Maksimova
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  2. O. V. Ershov
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  3. K. V. Lipin
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  4. A. V. Eremkin
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  5. O. E. Nasakin
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Correspondence to V. N. Maksimova.

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Original Russian Text © V.N. Maksimova, O.V. Ershov, K.V. Lipin, A.V. Eremkin, O.E. Nasakin, 2012, published in Zhurnal Organicheskoi Khimii, 2012, Vol. 48, No. 3, pp. 429–431.

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Maksimova, V.N., Ershov, O.V., Lipin, K.V. et al. Regioselective reaction of 5,6-dialkyl-2-halopyridine-3,4-dicarbonitriles with ammonia. Russ J Org Chem 48, 426–429 (2012). https://doi.org/10.1134/S1070428012030153

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  • DOI: https://doi.org/10.1134/S1070428012030153

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