Russian Journal of Organic Chemistry

, Volume 47, Issue 11, pp 1653–1674 | Cite as

Synthesis of epothilone D with the forced application of oxycyclopropane intermediates

Article

Abstract

The total synthesis of epothilone D with six-fold application in the intermediate stages of successive cyclopropanation — opening or cleavage of the three-membered ring was performed. These transformations underlie the new stereoselective method developed for coupling fragments C7–C12 and C13–C21 in the target molecule.

Keywords

Petroleum Ether Cyclopropane MsCl Tetrahydropyran Eluent Petroleum 

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Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  1. 1.Belorussian State UniversityMinskBelarus’

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