Three-component synthesis of spiro compounds with a carbamate functionality
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1,3-Dipolar cycloaddition of methyl 4-[2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)acetyl]phenylcarbamate to non-stabilized azomethine ylides generated by decarboxylation of α-amino acid (sarcosine and proline) adducts with ketones (isatin and ninhydrin) occurred regioselectively with formation of the corresponding spiro compounds having a carbamate moiety.
KeywordsIsatin Sarcosine Spiro Compound Phenylcarbamate Oxoethylidene
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