Ionic liquid-phase organic synthesis (IoLiPOS) methodology applied to cross aldol reaction
Cross aldol reaction in task-specific ionic liquids was developed. Ionic liquid-phase bound aldehyde reacted with various ketones (acetone, cyclopentanone, and butan-2-one) with l-proline as catalyst to afford various ionic liquid-phase supported aldols in yields ranging from 81 to 99%. Detachment of the aldol in MeOH was realized by transesterification using 15% of MeONa. The structure of intermediates in each step was verified by spectroscopic analysis.
KeywordsIonic Liquid Aldol Cyclopentanone Aldol Reaction MeONa
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