Three-component reaction of methyl 2,4-dioxo-4-phenylbutanoate and methyl 2,4-dioxopentanoate with aromatic aldehydes and propane-1,2-diamine and chemical properties of the products
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The reactions of methyl 2,4-dioxo-4-phenylbutanoate and methyl 2,4-dioxopentanoate with a mixture of an aromatic aldehyde and propane-1,2-diamine, depending on the initial reactant ratio, gave 4-acyl-1-(2-aminopropyl)-5-aryl-3-hydroxy-2,5-dihydro-1H-pyrrol-2-ones and 1,1′-(propane-1,2-diyl)bis(4-acetyl-3-hydroxy-5-phenyl-2,5-dihydro-1H-pyrrol-2-one). Reactions of substituted 1-(2-aminopropyl)-2,5-dihydro-1H-pyrrol-2-ones with aromatic amines and hydrazines were studied, and the structure of one of the products, 5-(2-aminopropyl)-3,4-diphenylpyrrolo[3,4-c]pyrazol-6-one, was proved by X-ray analysis.
KeywordsAromatic Aldehyde Lactam Carbonyl Group Enol Hydroxy Group Dione Hydrochloride Compound VIIe
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- 2.Khan, M.S.Y. and Gupta, M., Pharmazie, 2002, vol. 57, p. 377.Google Scholar
- 3.Gein, V.L., Shumilovskikh, E.V., Voronina, E.V., Saraeva, R.F., Gein, L.F., Ugrak, B.I., and Andreichikov, Yu.S., Russ. J. Gen. Chem., 1994, vol. 64, p. 1084.Google Scholar
- 5.Sheldrick, G.M., SHELX97. Programs for Crystal Structure Analysis, Göttingen, Germany: Univ. Göttingen, 1998.Google Scholar