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Russian Journal of Organic Chemistry

, Volume 46, Issue 6, pp 875–883 | Cite as

Three-component reaction of methyl 2,4-dioxo-4-phenylbutanoate and methyl 2,4-dioxopentanoate with aromatic aldehydes and propane-1,2-diamine and chemical properties of the products

  • V. L. Gein
  • N. N. Kasimova
  • Z. G. Aliev
  • M. I. Vakhrin
Article

Abstract

The reactions of methyl 2,4-dioxo-4-phenylbutanoate and methyl 2,4-dioxopentanoate with a mixture of an aromatic aldehyde and propane-1,2-diamine, depending on the initial reactant ratio, gave 4-acyl-1-(2-aminopropyl)-5-aryl-3-hydroxy-2,5-dihydro-1H-pyrrol-2-ones and 1,1′-(propane-1,2-diyl)bis(4-acetyl-3-hydroxy-5-phenyl-2,5-dihydro-1H-pyrrol-2-one). Reactions of substituted 1-(2-aminopropyl)-2,5-dihydro-1H-pyrrol-2-ones with aromatic amines and hydrazines were studied, and the structure of one of the products, 5-(2-aminopropyl)-3,4-diphenylpyrrolo[3,4-c]pyrazol-6-one, was proved by X-ray analysis.

Keywords

Aromatic Aldehyde Lactam Carbonyl Group Enol Hydroxy Group Dione Hydrochloride Compound VIIe 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • V. L. Gein
    • 1
  • N. N. Kasimova
    • 1
  • Z. G. Aliev
    • 2
  • M. I. Vakhrin
    • 1
  1. 1.Perm State Pharmaceutical AcademyPermRussia
  2. 2.Institute of Chemical Physics ProblemsRussian Academy of SciencesChernogolovka, Moscow oblastRussia

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