Russian Journal of Organic Chemistry

, Volume 46, Issue 4, pp 577–585 | Cite as

Opening of the extra ring in pheophorbide a methyl ester by the action of amines as a one-step method for introduction of additional fragments at the periphery of chlorin macroring

  • D. V. Belykh
  • E. A. Kopylov
  • I. V. Gruzdev
  • A. V. Kuchin
Article

Abstract

Opening of the extra ring in pheophorbide a methyl ester by the action of amines differing in the number, size, and structure of substituents on the nitrogen atom was studied with a view to synthesize chlorine e 6 13-carboxamides. Main factors restricting one-step preparation of 13-carboxamides with a desired substituent were revealed. The obtained experimental data can be used as a basis for predicting the possibility for onestep preparative synthesis of particular chlorin e 6 13-carboxamide via reaction with one or another amine.

Keywords

Methyl Ester Benzylamine Unshared Electron Pair Octylamine Hexylamine 

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Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  • D. V. Belykh
    • 1
  • E. A. Kopylov
    • 2
  • I. V. Gruzdev
    • 3
  • A. V. Kuchin
    • 1
  1. 1.Institute of Chemistry, Komi Research Center, Ural DivisionRussian Academy of SciencesSyktyvkarRussia
  2. 2.Syktyvkar State UniversitySyktyvkarRussia
  3. 3.Institute of Biology, Komi Research Center, Ural DivisionRussian Academy of SciencesSyktyvkarRussia

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