Russian Journal of Organic Chemistry

, Volume 44, Issue 9, pp 1374–1377 | Cite as

Synthesis of carbamate derivatives of coumarin and chromene

Article

Abstract

Condensation of methyl (3-hydroxyphenyl)carbamate with ethyl acetoacetate and ethyl benzoylacetate at room temperature, as well as with L-2-hydroxysuccinic acid on heating, in the presence of concentrated sulfuric acid gave the corresponding methyl (4-R-2-oxo-2H-chromen-7-yl)carbamates (R = Me, Ph, H). Condensation of methyl (3-hydroxyphenyl)carbamate with benzylidenemalononitrile or with aromatic aldehydes and malononitrile on heating in propan-2-ol in the presence of piperidine led to the formation of the corresponding methyl (4-aryl-2-amino-3-cyano-4H-chromen-7-yl)carbamates.

Keywords

Carbamate Concentrate Sulfuric Acid Malononitrile Ethyl Acetoacetate Light Yellow Crystal 

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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  1. 1.Astrakhan State UniversityAstrakhanRussia

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