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Russian Journal of Organic Chemistry

, Volume 44, Issue 8, pp 1211–1214 | Cite as

Reaction of 4,5-dichloro-3-trichloromethylisothiazole with heterocyclic amines

  • V. I. Potkin
  • Yu. S. Zubenko
  • S. K. Petkevich
Article

Abstract

4,5-Dichloro-3-trichloromethylisothiazole reacted with piperidine, morpholine, pyrrolidine, and piperazine in DMF to give 81–96% of the corresponding 5-amino-4-chloro-3-trichloromethylisothiazoles as a result of selective nucleophilic replacement of the 5-chlorine atom. Acylation of 4-chloro-5-(piperazin-1-yl)-3-trichloromethylisothiazole with acetyl chloride gave 4-chloro-5-(4-acetylpiperazin-1-yl)-3-trichloromethyl-isothiazole.

Keywords

Piperazine Acetyl Chloride Heterocyclic Amine Trichloromethyl Methylene Carbon Atom 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  • V. I. Potkin
    • 1
  • Yu. S. Zubenko
    • 1
  • S. K. Petkevich
    • 1
  1. 1.Institute of Physical Organic ChemistryNational Academy of Sciences of BelarusMinskBelarus

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