Russian Journal of Organic Chemistry

, Volume 44, Issue 6, pp 785–790 | Cite as

Pd-catalyzed alkylation of halogen-substituted steroids with organozinc compounds

  • G. V. Latyshev
  • N. V. Lukashev
  • I. P. Beletskaya
Article

Abstract

A general procedure has been developed for the introduction of hydrophobic alkyl groups into positions 6, 3, and 17 of steroid molecules via palladium-catalyzed Negishi reaction of halogen-substituted steroids with benzyl- and alkylzinc halides.

Keywords

Benzyl Bromide Dppf BINAP Steroid Molecule Anhydrous Dioxane 

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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  • G. V. Latyshev
    • 1
  • N. V. Lukashev
    • 1
  • I. P. Beletskaya
    • 1
  1. 1.Faculty of ChemistryMoscow State UniversityMoscowRussia

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