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Pd-catalyzed alkylation of halogen-substituted steroids with organozinc compounds

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Abstract

A general procedure has been developed for the introduction of hydrophobic alkyl groups into positions 6, 3, and 17 of steroid molecules via palladium-catalyzed Negishi reaction of halogen-substituted steroids with benzyl- and alkylzinc halides.

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Authors and Affiliations

  1. Faculty of Chemistry, Moscow State University, Vorob’evy gory 1, Moscow, 119992, Russia

    G. V. Latyshev, N. V. Lukashev & I. P. Beletskaya

Authors
  1. G. V. Latyshev
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  2. N. V. Lukashev
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  3. I. P. Beletskaya
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Correspondence to N. V. Lukashev.

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Dedicated to Prof. M. Yus on his 60th anniversary

Original Russian Text © G.V. Latyshev, N.V. Lukashev, I.P. Beletskaya, 2008, published in Zhurnal Organicheskoi Khimii, 2008, Vol. 44, No. 6, pp. 797–801.

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Latyshev, G.V., Lukashev, N.V. & Beletskaya, I.P. Pd-catalyzed alkylation of halogen-substituted steroids with organozinc compounds. Russ J Org Chem 44, 785–790 (2008). https://doi.org/10.1134/S107042800806002X

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  • DOI: https://doi.org/10.1134/S107042800806002X

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