Russian Journal of Organic Chemistry

, Volume 44, Issue 1, pp 124–127 | Cite as

An efficient procedure for the synthesis of Esomeprazole using a titanium complex with two chiral ligands

  • T. M. Khomenko
  • K. P. Volcho
  • N. I. Komarova
  • N. F. Salakhutdinov
Article

Abstract

A procedure has been proposed for the selective preparation of Esomeprazole via asymmetric oxidation of the corresponding prochiral sulfide in the presence of a catalytic complex derived from titanium(IV) isopropoxide and two different chiral ligands, diethyl d-tartrate and (R)-N,N-dimethyl-1-phenyl-ethanamine.

Keywords

Sodium Salt Esomeprazole Isopropoxide Optical Purity Mandelic Acid 

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Copyright information

© Pleiades Publishing, Ltd. 2008

Authors and Affiliations

  • T. M. Khomenko
    • 1
  • K. P. Volcho
    • 1
  • N. I. Komarova
    • 1
  • N. F. Salakhutdinov
    • 1
  1. 1.Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian DivisionRussian Academy of SciencesNovosibirskRussia

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