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Chemistry of naphthazarine derivatives: XIV. Preparative synthesis of 1′-bromoalkylnaphthazarines

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Abstract

A reaction of alkylnaphthazarines with bromine in tetrachloromethane was investigated. A preparative synthesis was developed for substituted 1′-bromoalkylnaphthazarines, and based on the substance 1′-hydroxyalkylnaphthazarines were prepared, analogs of shikalkin, a racemic mixture of plant pigments from Boraginaceae family. 2-Acyl-3-hydroxynaphthazarine was synthesized, a minor metabolite of urchin from genus Echinothrix.

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Authors and Affiliations

  1. Pacific Institute of Bioorganic Chemistry, Far-Eastern Division, Russian Academy of Sciences, Vladivostok, 690022, Russia

    N. D. Pokhilo, A. Ya. Yakubovskaya, V. F. Anufriev & D. V. Berdyshev

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  1. N. D. Pokhilo
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  2. A. Ya. Yakubovskaya
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  3. V. F. Anufriev
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  4. D. V. Berdyshev
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Correspondence to A. Ya. Yakubovskaya.

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Dedicated to the Full Member of the Russian Academy of Sciences V.A. Tartakovsky on occasion of his 75th birthday

Original Russian Text © N.D. Pokhilo, A.Ya. Yakubovskaya, V.F. Anufriev, D.V. Berdyshev, 2007, published in Zhurnal Organicheskoi Khimii, 2007, Vol. 43, No. 8, pp. 1177–1181.

For Communication I, see [1].

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Pokhilo, N.D., Yakubovskaya, A.Y., Anufriev, V.F. et al. Chemistry of naphthazarine derivatives: XIV. Preparative synthesis of 1′-bromoalkylnaphthazarines. Russ J Org Chem 43, 1170–1175 (2007). https://doi.org/10.1134/S1070428007080143

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  • DOI: https://doi.org/10.1134/S1070428007080143

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