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Russian Journal of Organic Chemistry

, Volume 43, Issue 4, pp 553–558 | Cite as

Heterocyclizations of functionalized heterocumulenes with C,N-, C,O-, and C,S-binucleophiles: VII. Reaction of 1-chloroalkyl isocyanates with N,N-disubstituted cyanothioacetamides. A new synthetic route to 6-dialkylamino-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitriles

  • V. A. Sukach
  • N. G. Chubaruk
  • M. V. Vovk
Article

Abstract

Reactions of α-chlorobenzyl isocyanates and 1-aryl-2,2,2-trifluoro-1-chloroethyl isocyanates with N,N-disubstituted cyanothioacetamides gave 3,4-dihydro-2H-1,3-thiazin-4-ones and 3-aryl-2-cyano-4,4,4-trifluorobut-2-enethioamides. The effect of substituents in the reactant molecules on the reaction course and product ratio was studied.

Keywords

Isocyanate Thioamide Cyanuric Acid Thiazine Anhydrous Toluene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Pleiades Publishing, Ltd. 2007

Authors and Affiliations

  • V. A. Sukach
    • 1
  • N. G. Chubaruk
    • 1
  • M. V. Vovk
    • 1
  1. 1.Institute of Organic ChemistryNational Academy of Sciences of UkraineKievUkraine

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