Russian Journal of Organic Chemistry

, Volume 43, Issue 4, pp 553–558 | Cite as

Heterocyclizations of functionalized heterocumulenes with C,N-, C,O-, and C,S-binucleophiles: VII. Reaction of 1-chloroalkyl isocyanates with N,N-disubstituted cyanothioacetamides. A new synthetic route to 6-dialkylamino-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitriles

  • V. A. Sukach
  • N. G. Chubaruk
  • M. V. Vovk


Reactions of α-chlorobenzyl isocyanates and 1-aryl-2,2,2-trifluoro-1-chloroethyl isocyanates with N,N-disubstituted cyanothioacetamides gave 3,4-dihydro-2H-1,3-thiazin-4-ones and 3-aryl-2-cyano-4,4,4-trifluorobut-2-enethioamides. The effect of substituents in the reactant molecules on the reaction course and product ratio was studied.


Isocyanate Thioamide Cyanuric Acid Thiazine Anhydrous Toluene 
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Copyright information

© Pleiades Publishing, Ltd. 2007

Authors and Affiliations

  • V. A. Sukach
    • 1
  • N. G. Chubaruk
    • 1
  • M. V. Vovk
    • 1
  1. 1.Institute of Organic ChemistryNational Academy of Sciences of UkraineKievUkraine

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