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Russian Journal of Organic Chemistry

, Volume 42, Issue 5, pp 735–738 | Cite as

Synthesis, structure, and cytotoxicity of O-[3-(5-tetrazolyl)propyl]oximes

  • K. Rubina
  • E. Abele
  • S. Belyakov
  • I. Shestakova
  • Yu. Popelis
Article

Abstract

A two-stage method was developed for the conversion of phenyl-and pyridylaldoximes and ketoximes into the corresponding O-[3-(5-tetrazolyl)propyl]oximes. The structure of the sodium salt of 2-acetylpyridine O-[3-(5-tetrazolyl)propyl]oxime was established X-ray diffraction analysis. This compound was shown to possess a high cytotoxic activity in vitro.

Keywords

Oxime Ketoxime High Cytotoxic Activity Tetrazole Derivative Tetraoctylammonium Bromide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Pleiades Publishing, Inc. 2006

Authors and Affiliations

  • K. Rubina
    • 1
  • E. Abele
    • 1
  • S. Belyakov
    • 1
  • I. Shestakova
    • 1
  • Yu. Popelis
    • 1
  1. 1.Latvian Institute of Organic ChemistryRigaLatvia

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