Russian Journal of Applied Chemistry

, Volume 88, Issue 12, pp 2065–2073 | Cite as

Green synthesis of thiazol-2-ylthiazolidin-4-ones as potential antifungals

Various Technological Processes

Abstract

MORE (Microwave oriented reaction enhancement) green methodology was utilized to synthesize benzothiazol/thiazol-2-ylthiazolidin-4-ones and relatively assayed for their antifungal activity w.r.t precursors against three agriculturally important phytopathogenic fungi viz. Colletotrichum falcatum, Pyricularia grisea and Ustilago hordei. Thiazol-2-ylthiazolidin-4-ones displayed better inhibition of growth of fungi than their precursor’s thiazol-2-amines, with some compounds showing results comparable to their standard fungicides endorsing the effectiveness of chemical hybridization of thiazoles/benzothiazoles with thiazolidin-4-ones in a single molecule. In silico toxicity of all the compounds was found to be equivalent to the standard fungicides. Lipinski parameters were used to rationalize structure activity relation using statistical analysis software.

Keywords

Thiazole Phytopathogenic Fungus Light Yellow Crystal Topological Polar Surface Area Antifungal Potential 

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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  1. 1.Department of ChemistryPunjab Agricultural UniversityLudhianaIndia
  2. 2.Department of Plant PathologyPunjab Agricultural UniversityLudhianaIndia

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