Russian Journal of Applied Chemistry

, Volume 88, Issue 11, pp 1793–1799 | Cite as

Synthesis of N-vinyl-2-pyrrolidone–3-butenoic acid copolymers as drug carriers

  • M. S. Borisenko
  • N. V. Zakharova
  • E. B. Tarabukina
  • M. V. Solovskii
Macromolecular Compounds and Polymeric Materials
  • 25 Downloads

Abstract

New water-soluble copolymers of N-vinylpyrrolidone with 3-butenoic acid were prepared by radical copolymerization initiated with azobis(isobutyronitrile) or γ-radiation. The relative activities of the monomers in copolymerization were determined. The distribution of the units in the copolymer macrochains was calculated. The composition, molecular and hydrodynamic characteristics, and acute toxicity of the copolymers were determined. The copolymers were used as carriers for rifampicin antibiotic.

Keywords

Rifampicin Copolymerization Hydrodynamic Radius Carboxy Group Radical Copolymerization 

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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • M. S. Borisenko
    • 1
  • N. V. Zakharova
    • 1
  • E. B. Tarabukina
    • 1
  • M. V. Solovskii
    • 1
  1. 1.Institute of Macromolecular CompoundsRussian Academy of SciencesSt. PetersburgRussia

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