Russian Journal of Applied Chemistry

, Volume 88, Issue 1, pp 160–168 | Cite as

Molecularly imprinted polymer for L-tyrosine recognition and controlled release

  • Xue-Fang Zheng
  • Qi Lian
  • Haixia Wu
  • Hongmei Liu
  • Shitao Song
Various Technologies

Abstract

Molecularly imprinted membranes (MIMs) with combined properties of molecular recognition and controlled release were prepared and characterized. MIMs were synthesized by the co-polymerization of chitosan (CS) and gelatine (GEL) in aqueous phase, using L-tyrosine as an imprinting molecule and polyethylene glycol (PEG) as a porogen. Binding experiments were carried out to evaluate the properties of MIMs and nonmolecularly imprinted membranes (NIMs). The results demonstrated that the MIMs with diameters of about 500 nm had high adsorption capacity and selectivity to L-tyrosine (L-tyr). Moreover, release profiles and release rate of L-tyrosine from the L-tyrosine-loaded MIMs indicated that the MIMs also had potential applications in drug controlled release.

Keywords

Chitosan Control Release Polyethylene Glycol Molecularly Imprint Polymer Sodium Hydroxide Solution 

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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • Xue-Fang Zheng
    • 1
  • Qi Lian
    • 1
  • Haixia Wu
    • 2
  • Hongmei Liu
    • 1
  • Shitao Song
    • 1
  1. 1.College of Chemical EngineeringHebei Normal University of Science and TechnologyQinhuangdaoChina
  2. 2.Chemical and Pharmaceutical EngineeringHebei University of Science and TechnologyShijiazhuangChina

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