Facile Synthesis of Novel Isoflavone/1,2,3-Triazole Hybrid Heterocycles as Potential Antimicrobial Agents

Abstract

A variety of new hybrid derivatives of isoflavone-1,2,3-triazole conjugated heterocycles has been synthesized from 7-hydroxy isoflavone by Cu(I) catalysed azidoalkyne [3+2]cycloaddition. The synthesized compounds have been tested for anti-bacterial activity against gram positive Bacillus subtilis, gram negative Escherichia coli and anti-fungal activity against Sclerotium Rolfsii, Macrophomina phaseolina. Three products demonstrate moderate activity against Bacillus subtilis and three compounds are characterized as highly anti-fungal agents for Sclerotium Rolfsii.

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ACKNOWLEDGMENTS

The authors are thankful to the Head, Department of Chemistry, Osmania University, Hyderabad, for providing Laboratory facilities and the Director, CFRD, Osmania University, Hyderabad, for providing spectral analysis facilities.

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Correspondence to J. Rao Yerrabelly.

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Yerrabelly, J.R., Mallepaka, P. Facile Synthesis of Novel Isoflavone/1,2,3-Triazole Hybrid Heterocycles as Potential Antimicrobial Agents. Russ J Gen Chem 90, 911–916 (2020). https://doi.org/10.1134/S1070363220050266

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Keywords:

  • 7-proporgyloxy isoflavones
  • dipolarcycloaddition
  • click chemistry
  • isoflavone-1,2,3-triazole
  • antimicrobial activity