A variety of new hybrid derivatives of isoflavone-1,2,3-triazole conjugated heterocycles has been synthesized from 7-hydroxy isoflavone by Cu(I) catalysed azidoalkyne [3+2]cycloaddition. The synthesized compounds have been tested for anti-bacterial activity against gram positive Bacillus subtilis, gram negative Escherichia coli and anti-fungal activity against Sclerotium Rolfsii, Macrophomina phaseolina. Three products demonstrate moderate activity against Bacillus subtilis and three compounds are characterized as highly anti-fungal agents for Sclerotium Rolfsii.
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The authors are thankful to the Head, Department of Chemistry, Osmania University, Hyderabad, for providing Laboratory facilities and the Director, CFRD, Osmania University, Hyderabad, for providing spectral analysis facilities.
No conflict of interest was declared by the authors.
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Yerrabelly, J.R., Mallepaka, P. Facile Synthesis of Novel Isoflavone/1,2,3-Triazole Hybrid Heterocycles as Potential Antimicrobial Agents. Russ J Gen Chem 90, 911–916 (2020). https://doi.org/10.1134/S1070363220050266
- 7-proporgyloxy isoflavones
- click chemistry
- antimicrobial activity