Synthesis of New 2-Substituted 5-Hydroxypyrano[2,3-d][1,3]oxazine-4,7-diones

Abstract

The reaction of carboxylic acid amides with malonyl chloride in acetonitrile or tetrahydrofuran without heating leads to the formation of previously unknown 2-substituted 5-hydroxypyrano[2,3-d][1,3]oxazines. The structure of the obtained compounds was established by high resolution mass spectrometry, NMR spectroscopy, and X-ray analysis.

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Fig. 1.
Scheme

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Correspondence to V. O. Komissarov.

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Komissarov, V.O., Chernov, N.M., Starova, G.L. et al. Synthesis of New 2-Substituted 5-Hydroxypyrano[2,3-d][1,3]oxazine-4,7-diones. Russ J Gen Chem 90, 757–759 (2020). https://doi.org/10.1134/S1070363220040325

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Keywords:

  • pyrano[2,3-d][1,3]oxazine
  • malonyl chloride
  • X-ray analysis