Synthesis and Anti-Proliferative Activity of Novel Tricyclic Compounds Derived from 2-Substituted 1,3-Indandione

Abstract

A new series of fused 1,3-indandione derivatives has been synthesized and evaluated for anti-proliferative activity. 2-Alkene-1,3-indandione derivatives have been used as the precursors of a number of tricyclic compounds. The latter have been tested for anti-proliferative activity.

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ACKNOWLEDGMENTS

Authors are grateful to King Saud University for funding the work through Researchers Supporting Project (project no. RSP-2019/66).

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Correspondence to A. E. Amr.

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Abd-Elghaffar, H.S., El-Hashash, M.A., Mohamed, S.F. et al. Synthesis and Anti-Proliferative Activity of Novel Tricyclic Compounds Derived from 2-Substituted 1,3-Indandione. Russ J Gen Chem 90, 686–696 (2020). https://doi.org/10.1134/S1070363220040209

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Keywords:

  • 1,3-indandione
  • anti-proliferative
  • p38αMAPK and ERK1/2 protein kinases
  • molecular modeling