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Synthesis, Structure and Biological Activity of Coordination Compounds of Copper, Nickel, Cobalt, and Iron with Ethyl N'-(2-Hydroxybenzylidene)-N-prop-2-en-1-ylcarbamohydrazonothioate

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Abstract

N-(Prop-2-en-1-yl)hydrazonocarbothioamide reacts with iodoethane in methanol with further addition of 2-hydroxybenzaldehyde to form hydroiodide of carbamohydrazonothioate (HL·HI). The coordination compounds were obtained by interaction of HL or HL·HI with copper, nickel, cobalt and iron salts CuLХ·nH2O [X = Cl–, Br–, NO3–; n = 0–1], Ni(L)2·HI·CH3OH, Сo(L)2X [X = I–, NO3–] and Fe(L)2NO3. The structures of three complexes were established by single crystal X-ray analysis. The synthesized complexes exhibit selective antimicrobial and antifungal activity against a series of standard microorganisms and fungi in the concentration range of 30–500 μg/mL. In addition, nickel and iron complexes selectively inhibit the growth and proliferation of cancer cells and do not adversely affect normal cells.

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ACKNOWLEDGMENTS

The authors express gratitude to O.S. Garbuz for the help in performance of biological tests of synthesized substances.

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Authors and Affiliations

  1. State University of Moldova, 2009, Chisinau, Moldova

    А. P. Gulea, I. S. Usataia, V. О. Graur & V. I. Tsapkov

  2. Institute of Applied Physics, 2001, Chisinau, Moldova

    Yu. M. Chumakov & P. A. Petrenko

  3. Gebze Institute of Technology, Cayirova, 41400, Kocaeli, Turkey

    Yu. M. Chumakov

  4. State University of Medicine and Pharmacy “Nicolae Testemitanu”, 2001, Chisinau, Moldova

    G. G. Balan & O. S. Burduniuc

  5. National Agency of Public Health, 2028, Chisinau, Moldova

    O. S. Burduniuc

  6. Institute of Microbiology and Biotechnology of Academy of Sciences of Moldova, 2028, Chisinau, Moldova

    V. F. Rudic

Authors
  1. А. P. Gulea
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  2. I. S. Usataia
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  3. V. О. Graur
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  4. Yu. M. Chumakov
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  5. P. A. Petrenko
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  6. G. G. Balan
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  7. O. S. Burduniuc
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  8. V. I. Tsapkov
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  9. V. F. Rudic
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Corresponding author

Correspondence to V. О. Graur.

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Gulea, А.P., Usataia, I.S., Graur, V.О. et al. Synthesis, Structure and Biological Activity of Coordination Compounds of Copper, Nickel, Cobalt, and Iron with Ethyl N'-(2-Hydroxybenzylidene)-N-prop-2-en-1-ylcarbamohydrazonothioate. Russ J Gen Chem 90, 630–639 (2020). https://doi.org/10.1134/S107036322004012X

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  • DOI: https://doi.org/10.1134/S107036322004012X

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