Three-Component Reaction of 1-(Oxyran-2-ylmethyl)-1H-indole-3-carbaldehyde with CH-Acids and Amines

Abstract

One-pot synthesis of 3-vinyl substituted indoles containing 1,2-amino alcohol fragment at the nitrogen atom was performed by the reactions of 1-(oxiran-2-ylmethyl)-1H-indole-3-carbaldehyde with methylene-active compounds and amines.

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Funding

This work was supported by the Southern Federal University.

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Correspondence to K. F. Suzdalev.

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Suzdalev, K.F., Vikrishchuk, N.I. & Tsiryulnik, S.A. Three-Component Reaction of 1-(Oxyran-2-ylmethyl)-1H-indole-3-carbaldehyde with CH-Acids and Amines. Russ J Gen Chem 90, 572–578 (2020). https://doi.org/10.1134/S1070363220040027

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Keywords:

  • indole
  • 1,2-aminoalcohol
  • amines
  • 1,3-dimethylbarbituric acid
  • indolin-2-one
  • malonic acid dinitrile