Skip to main content
SpringerLink
Log in

Imbricin, an Antibiotic of Nonmedical Application: Biological Activity, Environmental Friendliness, and Prospects for Use in Plant Protection

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

Biological experiments with imbricin, a nonmedical application antibiotic, were carried out. It was established that this macrolide nonpolyene antibiotic is an environmentally friendly preparation possessing antifungal, insecticidal, and phytoregulatory activities. The prospects for its application in plant protection against diseases and harmful arthropods, as well as for increasing the agricultural crop yield were shown.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Organic Food and Farming: A System Approach to Meet the Sustainability Challenge, Kolling, A., Ed., Brussels: IFOAM EU GROUP, 2010.

  2. Re-Thinking Organic Food and Farming in a Changing World, Freyer, B. and Bingen, J., Eds., Amsterdam: Springer, 2015.

    Google Scholar 

  3. Deciphering Organic Foods: A Comprehensive Guide to Organic Food Production, Consumption, and Promotion, Ioannis Kareklas, I. and Muehling, D.D., Eds., London: Nova Science, 2017.

    Google Scholar 

  4. Shternshis, M.V., Biologicheskaya zashchita rastenii (Biological Plant Protection), Moscow: KolosS, 2004.

    Google Scholar 

  5. Egorov, N.S., Osnovy ucheniya ob antibiotikakh (Basic Theory of Antibiotics), Moscow: Mosk. Gos. Univ., 6th ed., 2004, p. 492.

    Google Scholar 

  6. Pesticides in the Modern World–Pesticides Use and Management, Stoytcheva, M., Ed., Rijeka (Croatia): InTech, 2011.

  7. Matthews, G.A., Pesticides: Health, Safety and the Environment, 2nd ed., New York: Wiley-Blackwell, 2015.

    Book  Google Scholar 

  8. Nollet, L.M.L. and Rathore, H.S., Biopesticides Handbook, Boca Raton (FL, USA): CRC Press Taylor & Francis Group, 2015.

    Book  Google Scholar 

  9. Basic and Applied Aspects of Biopesticides, Sahayaraj, K., Ed., New Delhi: Springer, 2014.

  10. Biopesticides: State of the Art and Future Opportunities, Gross, A., Coats, J.R., Duke, S.O., and Seiber, J.N., Eds., Washington: Chemical Society, 2015.

    Google Scholar 

  11. Golovleva, L.A. and Chermenskii, D.N., Agrokhimiya, 1988, no. 1, p. 130.

    Google Scholar 

  12. Roslavtseva, S.A., Agrokhimiya, 1987, no. 7, p. 130.

    Google Scholar 

  13. Antibiotics: Current Innovations and Future Trends, Sanchez, S. and Demain, A.L., Eds., Norfolk (UK): Caister Academic Press, 2015, p. 113.

  14. Hook, D.J., in Basic Biotechnology, Ratledge, C. and Kristiansen, B., Eds., 3rd ed., Cambridge (UK): Cambridge Univ. Press, 2006, p. 433.

    Google Scholar 

  15. Corcoran, J.W., Biosynthesis, Berlin-Heidelberg: Springer, 2012.

    Google Scholar 

  16. Martin, J.-F., Garcia-Estrada, C., and Zeilinger, S., Biosynthesis and Molecular Genetics of the Fungal Secondary Metabolites, New York: Springer, 2014.

    Book  Google Scholar 

  17. Belakhov, V.V., Yakovleva, E.P., Kolodyaznaya, V.A., Boikova, I.V., Russ. J. Gen. Chem., 2017, vol. 87, no. 13, p. 3220. doi https://doi.org/10.1134/S1070363217130175

    Article  CAS  Google Scholar 

  18. Pimenova, M.N., Grechushkina, N.N., Azova, L.G., Netrusov, A.I., Semenova, E.V., Zakharchuk, L.M., Zinchenko, V.V., Kolotilova, N.N., Myl’nikova, S.I., Nefelova, M.V., and Botvinko, I.V., Rukovodstvo po prakticheskim zanyatiyam po mikrobiologii (Guide to Practical Training in Microbiology), Moscow: Mosk. Gos. Univ., 1995.

    Google Scholar 

  19. Mobius, D., Miller, R., and Fainerman, V.B., Surfactants: Chemistry, Interfacial Properties, Applications, Amsterdam: Elsevier Science, vol. 13, 2001.

    Google Scholar 

  20. TU (Technical Specifications) 2483-077-05766801-98: Neonols.

  21. RF Patent 2160311, Byull. Izobret. Polez. Mod., no. 2, 2001.

  22. RF Patent 2314691, Byull. Izobret. Polez. Mod., no. 5, 2008.

  23. Tsyganov, V.A., Konev, Yu.E., Barashkova, N.P., Petrova, L.Ya., and Solov’ev, S.N., Antibiotiki, 1970, vol. 15, no. 3, p. 208.

    CAS  Google Scholar 

  24. Sukharevich, M.E., Cand. (Biol.) Sci. Dissertation, St. Petersburg: Sankt-Peterb. Gos. Khim.-Farm. Akad., 1997.

    Google Scholar 

  25. Sukharevich, M.E., Yakovleva, E.P., Borisova, O.G., and Sukharevich, V.I., Antibiot. Khimioter., 1998, vol. 43, no. 12, p. 12.

    CAS  PubMed  Google Scholar 

  26. Arai, M., J. Antibiot., Ser. A, 1960, vol. 13, p. 46.

    CAS  Google Scholar 

  27. Arai, M., Arzneimittel-Forsch., 1968, vol. 18, no. 11, p. 1396.

    CAS  Google Scholar 

  28. Arai, M. and Hamano, K., J. Antibiot., 1970, vol. 23, p. 107.

    Article  CAS  PubMed  Google Scholar 

  29. Iwasaki, S., Namikoshi, M., Sasaki, K., Fukushima, K., and Okuda, S., Chem. Pharm. Bull., 1982, vol. 30, no. 11, p. 4006.

    Article  CAS  Google Scholar 

  30. Kolosov, M.N., Onoprienko, V.V., Gladkova, L.N., Karapetyan, M.G., Mamedov, F.A., and Nikonov, A.L., in Abhandl. Akad. Wissensch. DDR, Abt. Math., Naturwissensch., Technik, Berlin: Akademie, 1983, no. 1N, p. 55.

    Google Scholar 

  31. Bashkovich, A.P., Zimnukhova, E.S., Prokopovich, A.V., Tsyganov, V.A., Kul’bakh, V.O., Kil’fin, G.I., Morgunova, A.F., Ostraya, I.A., and Petrova, L.Ya., USSR Inventor’s Certificate no. 420258, Byull. Izobret., 1974, no. 41, p. 157.

    Google Scholar 

  32. Rozdov, I.A. and Bol’shakova E.A., Tezisy dokladov k nauchno-prakticheskoi konferentsii “Progressivnye, ekologicheski bezopasnye tekhnologii khraneniya i kompleksnoi pererabotki sel’khozproduktsii dlya sozdaniya produktov pitaniya povyshennoi pishchevoi i biologicheskoi tsennosti” (Abstracts of Papers of the Sci. and Practical Conf. “Advanced, Ecofriendly Technologies for Storage and Integrated Processing of Agricultural Products for Creating Food Products of Increased Nutritional and Biological Value”), Moscow: Ross. Akad. Sel’skokhoz. Nauk, 1999, p. 340.

    Google Scholar 

  33. Snezhko, A.G., Borisova, Z.S., Rozdov, I.A., Eliseeva, N.N., Skripko, L.A., Gavrikova, M.A., Slepukhina, V.S., and Krasnova, T.A., RF Patent 2007924, 1994.

    Google Scholar 

  34. Snezhko, A.G., Kuznetsova, L.S., Borisova, Z.S., and Kholodova, A.P., RF Patent 2170025, 2001.

    Google Scholar 

  35. Snezhko, A.G., Gubanova, M.I., Ramanauskas, R., Galginaitine, L., Syrodel. Maslodel., 2013, no. 3, p. 17.

    Google Scholar 

  36. Kuzikova, I.L., Cand. (Biol.) Sci. Dissertation, St. Petersburg: Sankt-Peterb. Nauchno-Issled. Tsentr Ekol. Bezopasnosti Ross. Akad. Nauk, 2004.

    Google Scholar 

  37. Dobrusina, S.A., Doctoral (Tech.) Dissertation, St. Petersburg: Ross. Nats. Bibliioteka, 1996.

    Google Scholar 

  38. Shchukarev, A.V., Dobrusina, S.A., Sukharevich, V.I., and Lotsmanova, E.M., Zh. Prikl. Khim., 1995, vol. 68, no. 10, p. 1680.

    CAS  Google Scholar 

  39. Dobrusina, S.A., Medvedeva, N.G., Lotsmanova, E.M., and Sukharevich, M.E., Mikol. Fitopatol., 1997, vol. 31, no. 2, p. 54.

    CAS  Google Scholar 

  40. Dobrusina, S.А., Sukharevich, V.I., Lotsmanova, E.M., Pokrovskaya, Yu.V., and Medvedeva, N.G., RF Patent 2048007, Byull. Izobret., 1995, no. 15.

    Google Scholar 

  41. Sukharevich, V.I., Kuzikova, I.L., and Medvedeva, N.G., Zashchita ot biopovrezhdenii, vyzyvaemykh gribami (Protection against Biodeterioration Caused by Fungi), St. Petersburg: ELBI-SPb, 2009.

    Google Scholar 

  42. Khodzhibaeva, S.M., Doctoral (Biol.) Dissertation, St. Petersburg: Vseross. Nauchno-Issled. Inst. Zashch. Rast., 1992.

    Google Scholar 

  43. Khodzhibaeva, S.M., Mamedova, S.R., Bashkovich, A.P., and Shirai, L.P., USSR Inventor’s Certificate no. 1506609, 1989.

    Google Scholar 

  44. Khalmuradov, A.G., Shtok, D.A., and Khodzhibaeva, S.M., USSR Inventor’s Certificate no. 1522447, 1989.

    Google Scholar 

  45. Mamedova, S.R., Cand. (Biol.) Sci. Dissertation, Tashkent: Inst. Mikrobiol. Akad. Nauk Resp. Uzbekistan, 2000.

    Google Scholar 

  46. Mamedova, S.R., Khodzhibaeva, S.M., and Nazirova, E.R., Uzbek Biol. Zh., 1997, no. 4, p. 13.

    Google Scholar 

  47. Mamedova, S.R. and Khodzhibaeva, S.M., Dokl. Akad. Nauk Resp. Uzbekistan, no. 9, p. 41.

  48. Carlile, W.R., Control of Crop Diseases, 3rd ed., Cambridge: Cambridge Univ. Press, 2012.

    Book  Google Scholar 

  49. Sokirko, V.P., Gor’kovenko, V.S., and Zazimko, M.I., Fitopatogennye griby (morfologiya i sistematika) [Phytopathogenic Fungi (Morphology and Systematics)], Krasnodar: Kuban. Gos. Agrar. Univ., 2014.

    Google Scholar 

  50. Matthews, G.A., Bateman, R., and Miller, P., Pesticide Application Methods, 4th ed., New York: Wiley, 2014.

    Book  Google Scholar 

  51. Glazko, V.I., Russ. J. Agric. Socio-Econ. Sci., 2016, vol. 8, no. 56, p. 74.

    Google Scholar 

  52. Novikova, I.I., Popova, E.V., Boikova, I.V., Pavlyushin, V.A., and Tyuterev, S.L., Zashch. Karant. Rast., 2016, no. 8, p. 35.

    Google Scholar 

  53. Shkalikov, V.A., Zashchita rastenii ot boleznei (Plant Protection against Diseases), Moscow: KolosS, 2010.

    Google Scholar 

  54. Zinchenko, V.A., Khimicheskaya zashchita rastenii: sredstva, tekhnologiya i ekologicheskaya bezopasnost’ (Chemical Plant Protection: Means, Technology, and Environmental Safety), Moscow: KolosS, 2012.

    Google Scholar 

  55. Buchenauer, H. and Walker, F., in Modern Crop Protection Compounds, 2nd ed., Kramer, W., Schirmer, U., Jeschke, P., and Witschel, M., Eds., Weinheim (Germany): Wiley-VCH, 2012, vol. 2, p. 693.

    Article  CAS  Google Scholar 

  56. Pesticide Chemistry: Crop Protection, Public Health, Environmental Safety, 1 ed., Okawa, H., Mijagawa, H., and Lee, P.W., Eds., Weinheim (Germany): Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

    Google Scholar 

  57. Oliver, R. and Oliver, R.P., Fungicides in Crop Protection, 2nd ed., Oxfordshire (UK): CABI, 2014.

    Book  Google Scholar 

  58. Soldatenkov, A.T., Kolyadina, N.M., and Le Tuan, A., Pestitsidy i regulyatory rosta (Pesticides and Growth Regulators), Moscow: BINOM, 2010, p. 17.

    Google Scholar 

  59. Popova, L.M., Kurzin, A.V., and Evdokimov, A.N., Pestitsidy (Pesticides), St. Petersburg: Prospekt Nauki, 2013, p. 65.

    Google Scholar 

  60. Onstad, D.W., Insect Resistance Management: Biology, Economics, and Prediction, New York: Barnes & Noble, 2007.

    Google Scholar 

  61. Watson, D., Pesticide Management and Insecticide Resistance, New York: Elsevier Science, 2012.

    Google Scholar 

  62. Gosudarstvennyi katalog pestitsidov i agrokhimikatov, razreshennykh k primeneniyu na territorii Rossiiskoi Federatsii (State Catalog of Pesticides and Agricultural Chemicals Permitted for Use within the Territory of the Russian Federation), Moscow: Min. Sel’sk. Khoz. Ross. Fed., 2018.

  63. Greene, S.A., Sittig’s Handbook of Pesticides and Agricultural Chemicals, Norwich, New York: William Andrew, 2005.

    Google Scholar 

  64. McManus, P.S., Stockwell, V.O., Sundin, G.W., and Jones, A.L., Annu. Rev. Phytopathol., 2002, vol. 40, p. 443.

    Article  CAS  PubMed  Google Scholar 

  65. Kumar, K., Gupta, S.C., Chander, Y., and Singh, A.K., in Advances in Agronomy, Sparks, D., Ed., Oxford (UK): Elsevier, 2005, vol. 87, p. 1.

    CAS  Google Scholar 

  66. Novikova, I.I., Vestn. Zashch. Rast., 2016, vol. 83, no. 3, p. 120.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Microbiological Plant Protection Laboratory, All-Russian Institute of Plant Protection, St. Petersburg, Russia

    I. V. Boikova & I. I. Novikova

  2. Department of Biotechnology, St. Petersburg State Chemical-Pharmaceutical University, St. Petersburg, Russia

    E. P. Yakovleva & V. A. Kolodyaznaya

  3. Schulich Faculty of Chemistry, Technion – Israel Institute of Technology, Haifa, Israel

    V. V. Belakhov

Authors
  1. I. V. Boikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. I. Novikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. P. Yakovleva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. A. Kolodyaznaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. V. Belakhov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. V. Belakhov.

Additional information

Original Russian Text © I.V. Boikova, I.I. Novikova, E.P. Yakovleva, V.A. Kolodyaznaya, V.V. Belakhov, 2018, published in Ekologicheskaya Khimiya, 2018, Vol. 27, No. 5, pp. 233–245.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Boikova, I.V., Novikova, I.I., Yakovleva, E.P. et al. Imbricin, an Antibiotic of Nonmedical Application: Biological Activity, Environmental Friendliness, and Prospects for Use in Plant Protection. Russ J Gen Chem 88, 2937–2947 (2018). https://doi.org/10.1134/S1070363218130182

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070363218130182

Keywords

Search

Navigation