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Synthesis of 2-Amino-5-hydroxy-5-phosphonovaleric Acid

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Abstract

The synthesis of a new analog of 2-amino-5-phosphonovaleric acid (AP5), namely 2-amino-5-hydroxy-5-phosphonovaleric acid, by successive Michael addition of acetamidomalonic ester to acrolein and Abramov’s phosphorylation of the aldehydes formed in situ was developed.

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Authors and Affiliations

  1. Institute of Physiologically Active Substances of the Russian Academy of Sciences, Severnyi proezd 1, Chernogolovka, 142432, Russia

    V. V. Ragulin

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  1. V. V. Ragulin
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Correspondence to V. V. Ragulin.

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Dedicated to the 110th anniversary of M.I. Kabachnik’s birth

Original Russian Text © V.V. Ragulin, 2018, published in Zhurnal Obshchei Khimii, 2018, Vol. 88, No. 9, pp. 1547–1549.

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Ragulin, V.V. Synthesis of 2-Amino-5-hydroxy-5-phosphonovaleric Acid. Russ J Gen Chem 88, 1915–1917 (2018). https://doi.org/10.1134/S1070363218090256

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  • DOI: https://doi.org/10.1134/S1070363218090256

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