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Russian Journal of General Chemistry

, Volume 88, Issue 4, pp 815–824 | Cite as

Synthesis and Anti-H5N1 Activity of Substituted Pyridine Glycosides and (Oxadiazolyl)oxymethylpyridine Acyclic C-Nucleoside Analogues

  • H. A. Soliman
  • E. R. Kotb
  • M. N. El-Bayaa
  • O. M. Kutkat
  • F. M. E. Abdel-Magied
Article
  • 31 Downloads

Abstract

New aryl- and heteroaryl-substituted pyridinyl sugar hydrazones and their derivatives, 1,3,4-oxadiazole acyclic C-nucleosides, were synthesized. Novel O-glycoside derivatives of the substituted pyridines were prepared. The antiviral activity against avian influenza H5N1 virus was studied and compounds 5a, 9a, and 14 demonstrated high inhibition activity.

Keywords

pyridine sugar hydrazones oxadiazole acyclic nucleosides H5N1 virus 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • H. A. Soliman
    • 1
  • E. R. Kotb
    • 1
  • M. N. El-Bayaa
    • 1
  • O. M. Kutkat
    • 2
  • F. M. E. Abdel-Magied
    • 1
  1. 1.Photochemistry DepartmentNational Research CentreDokki, GizaEgypt
  2. 2.Environmental Research DivisionNational Research CenterDokki, CairoEgypt

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