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Synthesis and Anti-H5N1 Activity of Substituted Pyridine Glycosides and (Oxadiazolyl)oxymethylpyridine Acyclic C-Nucleoside Analogues

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Abstract

New aryl- and heteroaryl-substituted pyridinyl sugar hydrazones and their derivatives, 1,3,4-oxadiazole acyclic C-nucleosides, were synthesized. Novel O-glycoside derivatives of the substituted pyridines were prepared. The antiviral activity against avian influenza H5N1 virus was studied and compounds 5a, 9a, and 14 demonstrated high inhibition activity.

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Authors and Affiliations

  1. Photochemistry Department, National Research Centre, Dokki, Giza, 12622, Egypt

    H. A. Soliman, E. R. Kotb, M. N. El-Bayaa & F. M. E. Abdel-Magied

  2. Environmental Research Division, National Research Center, Dokki, Cairo, 12622, Egypt

    O. M. Kutkat

Authors
  1. H. A. Soliman
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  2. E. R. Kotb
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  3. M. N. El-Bayaa
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  4. O. M. Kutkat
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  5. F. M. E. Abdel-Magied
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Correspondence to E. R. Kotb.

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Soliman, H.A., Kotb, E.R., El-Bayaa, M.N. et al. Synthesis and Anti-H5N1 Activity of Substituted Pyridine Glycosides and (Oxadiazolyl)oxymethylpyridine Acyclic C-Nucleoside Analogues. Russ J Gen Chem 88, 815–824 (2018). https://doi.org/10.1134/S1070363218040291

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  • DOI: https://doi.org/10.1134/S1070363218040291

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