Russian Journal of General Chemistry

, Volume 88, Issue 4, pp 812–814 | Cite as

Synthesis and Antimicrobial Activity of 3-(1-Aryl-1H-1,2,3-triazol-4-yl)-2-(4-fluorophenyl)-1-(2-hydroxy-4-methoxyphenyl)propan-1-ones

  • M. Nagamani
  • Ch. Anjaiah
  • D. Praveen
  • P. Jalapathi
Article
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Abstract

A number of novel 3-(1-aryl-1H-1,2,3-triazol-4-yl)-2-(4-fluorophenyl)-1-(2-hydroxy-4-methoxyphenyl) propan-1-ones has been synthesized from 2-(4-fluorophenyl)-1-(2-hydroxy-4-methoxyphenyl)ethanone by its propargylation followed by the click reaction. Structures of all the newly synthesized compounds were characterized by 1H and 13C NMR, and Mass spectra. Their antimicrobial activity was evaluated.

Keywords

fluorinated organic molecule propargylation click reaction 1,2,3-triazole antimicrobial activity 

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Notes

Acknowledgments

The authors are thankful to the Head, Department of Chemistry for providing laboratory facilities. The authors are also thankful to the Director, Central Facilities for Research and Development (CFRD), Osmania University for providing IR and NMR spectral analysis and also thankful to University College of Science, Saifabad, Osmania University.

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • M. Nagamani
    • 1
  • Ch. Anjaiah
    • 2
  • D. Praveen
    • 1
  • P. Jalapathi
    • 1
  1. 1.Department of Chemistry, University College of Science, SaifabadOsmania UniversityHyderabad, TelanganaIndia
  2. 2.Department of Chemistry, University College of ScienceOsmania UniversityHyderabad, TelanganaIndia

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