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Synthesis, Molecular Docking, Analgesic, and Anti-Inflammatory Activities of New 1,2,4-Oxadiazolo-Sulfonamides

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Abstract

In the present study novel 1,2,4-oxadiazolo sulfonamides 3a–3o are synthesized by an efficient method based on the reaction of 1,2,4-oxadiazole amines with aryl sulfonyl chlorides. Structures of the synthesized compounds are confirmed by IR, NMR and Mass spectra. Molecular interactions of the obtained compounds are studied by Discovery Studio v3.5, molecular docking with COX-2 enzyme. The compounds with high LibDock score are screened for their in vivo analgesic and anti inflammatory activities. The compound 3l demonstrates the highest activity.

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Acknowledgments

Authors express their thanks to Head-Department of University College of Technology, Osmania University and management of RBVRR Women’s College of Pharmacy for their constant support and providing necessary facilities.

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Authors and Affiliations

  1. Department of Pharmacy, Faculty of Technology, Osmania University, Hyderabad, 500007, India

    M. Vijaya Bhargavi & P. Shashikala

  2. RBVRR Women’s College of Pharmacy, Osmania University, Hyderabad, 500007, India

    M. Vijaya Bhargavi & M. Sumakanth

  3. Department of Chemistry, Osmania University, Hyderabad, 500007, India

    C. Krishna

Authors
  1. M. Vijaya Bhargavi
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  2. P. Shashikala
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  3. M. Sumakanth
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  4. C. Krishna
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Correspondence to M. Vijaya Bhargavi.

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The text was submitted by the authors in English.

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Vijaya Bhargavi, M., Shashikala, P., Sumakanth, M. et al. Synthesis, Molecular Docking, Analgesic, and Anti-Inflammatory Activities of New 1,2,4-Oxadiazolo-Sulfonamides. Russ J Gen Chem 88, 804–811 (2018). https://doi.org/10.1134/S1070363218040278

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  • DOI: https://doi.org/10.1134/S1070363218040278

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