Advertisement

Russian Journal of General Chemistry

, Volume 88, Issue 4, pp 774–779 | Cite as

Synthesis, Antimicrobial Activity, and Docking Studies of 2-Mercapto Substituted Quinazolin-4(3H)-one and Their Derivatives

  • P. Balaswamy
  • S. Aravind
  • S. Purushotham Reddy
  • B. Satyanarayana
Article

Abstract

An efficient, eco-friendly synthesis of a series of 2-{[3-oxo-3-(alkyl/aryl-1-yl)alkyl]thio}-3-substituted quinazolin-4(3H)-ones employing quinazolin-4(3H)-one and corresponding halo-acyl/haloalkyl as electrophiles is presented. The products were assayed for anti-bacterial activity on four bacterial species (Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, and Staphylococcus aureus). In-silico molecular docking studies were carried out.

Keywords

quinazolin-4(3H)-one derivatives antibacterial activity molecular docking 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Notes

Acknowledgments

The author Balaswamy Puligilla is thankful to Central Electrochemical Research Institute (CSIR) for providing financial assistance and Department of Chemistry, Osmania University for providing facility, constant support and encouragement.

References

  1. 1.
    Kumar, A., Sharma, P., Kumari, P., and Kalal, B.L., Bioorg. Med. Chem. Let., 2011, vol. 21, p. 4353. doi 10.1016/j.bmcl.2011.05.031CrossRefGoogle Scholar
  2. 2.
    Veena Vani, K., Ramesh, G., and Venkata Rao, C., J. Het. Chem., 2016, vol. 53, p. 719. doi 10.1002/jhet.2353CrossRefGoogle Scholar
  3. 3.
    Jatav, V., Kashaw, S., and Mishra, P., Med. Chem. Res., 2008, vol. 17, p. 205. doi 10.1007/s00044-007-9054-3CrossRefGoogle Scholar
  4. 4.
    Aly, A.A., Chin. J. Chem., 2003, vol. 21, p. 339. doi 10.1002/cjoc.20030210324CrossRefGoogle Scholar
  5. 5.
    Bouley, R., Ding, D., Peng, Z., Bastian, M., Lastochkin, E., Song, W., and Chang, M., J. Med. Chem., 2016, vol. 59, p. 5011. doi 10.1021/acs.jmedchem.6b00372CrossRefGoogle Scholar
  6. 6.
    Amantini, D., Fringuelli, F., Pizzo, F., and Vaccaro, L., J. Org. Chem., 2001, vol. 66, p. 6734. doi 10.1021/jo015814sCrossRefGoogle Scholar
  7. 7.
    Khurana, J.M. and Kumar, S., Tetrahedron Lett., 2009, vol. 50, p. 4125. doi 10.1016/j.tetlet.2009.04.125CrossRefGoogle Scholar
  8. 8.
    Schrödinger, L.L.C., Glide, Version 4.0. New York, 2005.Google Scholar
  9. 9.
    Friesner, R.A., Banks, J.L., Murphy, R.B., Halgren, T.A., Klicic, J.J., Mainz, D.T., and Shenkin, P.S., J. Med. Chem., 2004, vol. 47, p. 1739. doi 10.1021/jm0306430CrossRefGoogle Scholar
  10. 10.
    Qikprop 3.4, Schrödinger, L.L.C, New York, 2010.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • P. Balaswamy
    • 1
  • S. Aravind
    • 1
  • S. Purushotham Reddy
    • 1
  • B. Satyanarayana
    • 1
  1. 1.Department of ChemistryOsmania UniversityHyderabad, TelanganaIndia

Personalised recommendations