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Russian Journal of General Chemistry

, Volume 88, Issue 4, pp 676–681 | Cite as

Synthesis and Antibacterial Activity of 9-Oxo-9,10-dihydroacridinecarboxylic Acids Esters Bearing a Triazole Fragment

  • T. N. Kudryavtseva
  • A. Yu. Lamanov
  • L. G. Klimova
  • G. V. Nazarov
Article
  • 21 Downloads

Abstract

An effective method for the synthesis of new acridine-9(10H)-one (acridone) derivatives containing 1,2,3-triazole fragment was developed. A number of new triazole-containing compounds were synthesized from propargyl acridone acetate and their antimicrobial activity was studied.

Keywords

acridone triazole nitrofuran antibacterial activity 

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Notes

Acknowledgments

This work was financially supported by the Ministry of Education and Science of Russia (project no. 4.9516.2017/BCh).

References

  1. 1.
    Kant, R., Singh, V., Nath, G., Awasthi, S.K., and Agarwal, A., Eur. J. Med. Chem., 2016, vol. 124, p. 218. doi 10.1016/j.ejmech. 2016.08.031CrossRefPubMedGoogle Scholar
  2. 2.
    Wang, Y., Cong, C., Chai, W.C., Dong, R., Jia, L., Song, D., Zhou, Z., and Ma, S., Bioorg. Med. Chem.Lett., 2017, vol. 27, no. 16, p. 3872. doi 10.1016/j.bmcl.2017.06.044CrossRefPubMedGoogle Scholar
  3. 3.
    Kudryavtseva, T.N., Lamanov, A.Yu., Klimova, L.G., and Nazarov, G.V., Russ. Chem. Bull., 2017, vol. 66, no. 1, p. 123. doi 10.1007/s11172-017-1709-8CrossRefGoogle Scholar
  4. 4.
    Lamanov, A.Yu. and Kudryavtseva, T.N., Fluorine Notes, 2013, no. 2 (89). http://notes.fluorine1.ru/-public/2015/2_2015/letters/rusindex.html.
  5. 5.
    Ershov, F.I., Romantsov, M.G., Kovalenko, A.L., Isakov, V.A., and Aspel’, Yu.V., Tsikloferon: itogi i perspektivy klinicheskogo primeneniya (Cycloferon: Results and Prospects of Clinical Use), St. Petersburg: NTFF “Polisan,” 1999.Google Scholar
  6. 6.
    Szulc, Z., Mlochowski, J., and Palus, J., J. Prakt. Chem., 1988, vol. 330, no. 6, p. 1023. doi 10.1002/prac.19883300625CrossRefGoogle Scholar
  7. 7.
    Gensicka-Kowalewska, M., Cholewińskia, G., and Dzierzbicka, K., RSC Adv., 2017, no. 7, p. 15776. doi 10.1039/C7RA01026ECrossRefGoogle Scholar
  8. 8.
    Malachowska-Ugarte, M., Cholewinski, G., Dzierzbicka, K., and Trzonkowski, P., Eur. J. Med. Chem., 2012, vol. 54, p. 197. doi 10.1016/j.ejmech.2012.04.040CrossRefPubMedGoogle Scholar
  9. 9.
    Meldal, M. and Tornøe, C.W., Chem. Rev., 2008, vol. 108, no. 8, p. 2952. doi 10.1021/cr0783479CrossRefPubMedGoogle Scholar
  10. 10.
    Singh, M.S., Chowdhury, S., and Koley, S., Tetrahedron, 2016, vol. 72, no. 35, p. 5257. doi 10.1016/j.tet.2016.07.044CrossRefGoogle Scholar
  11. 11.
    Dheer, D., Singh, V., and Shankar, R., Bioorg. Chem., 2017, vol. 71, p. 30. doi 10.1016/j.bioorg.2017.01.010CrossRefPubMedGoogle Scholar
  12. 12.
    Banday, A.H., Shameem, S.A., and Ganai, B.A., Org. Med. Chem. Lett., 2012, no. 2, p. 13. doi 10.1186/2191-2858-2-13.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Tron, G.C., Pirali, T., Billington, R.A., Canonico, P.L., Sorba, G., and Genazzani, A.A., Med. Res. Rev., 2008, vol. 28, no. 2, p. 278. doi 10.1002/med.20107CrossRefPubMedGoogle Scholar
  14. 14.
    Yempala, T., Sridevi, J.P., Yogeeswari, P., Sriram, D., and Kantevari, S., Eur. J. Med. Chem., 2014, vol. 71, p. 160. doi 10.1016/j.ejmech.2013.10.082CrossRefPubMedGoogle Scholar
  15. 15.
    Gosudarstvennaya farmakopeya Rossiiskoi Federatsii (State Pharmacopoeia of the Russian Federation), Moscow: Nauchnyi Tsentr Ekspertizy Sredstv Meditsinskogo Primeneniya, 2007, pt 1.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • T. N. Kudryavtseva
    • 1
  • A. Yu. Lamanov
    • 1
  • L. G. Klimova
    • 2
  • G. V. Nazarov
    • 1
  1. 1.Kursk State UniversityKurskRussia
  2. 2.Kursk State Medical UniversityKurskRussia

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