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Synthesis and Antimicrobial Activity of (Z)-3-{[3-Oxobenzofuran-2(3H)-ylidene]methyl}-4H-chromen-4-one Derivatives

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Abstract

A series of (Z)-3-{[3-oxobenzofuran-2(3H)-ylidene]methyl}-4H-chromen-4-one derivatives have been synthesized from 2-hydroxyl acetophenones by the Vilesmeier–Haack reaction, Claisen–Schmidt reaction and mercury(II) acetate/cupric bromide. All the synthesized compounds were characterized by IR, 1H and 13C NMR, and mass spectral data and elemental analysis. The products were tested for their in vitro antimicrobial activity.

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Authors and Affiliations

  1. Department of Chemistry, Jawaharlal Nehru Technological University, Hyderabad, Telangana, 500085, India

    S. Pervaram & C. V. R. Reddy

  2. Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana, 500007, India

    D. Ashok & B. A. Rao

  3. Department of Chemistry, Satavahana University, Karimnagar, Telangana, 505001, India

    M. Sarasija

Authors
  1. S. Pervaram
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  2. D. Ashok
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  3. C. V. R. Reddy
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  4. M. Sarasija
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  5. B. A. Rao
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Corresponding author

Correspondence to D. Ashok.

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The text was submitted by the authors in English.

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Pervaram, S., Ashok, D., Reddy, C.V.R. et al. Synthesis and Antimicrobial Activity of (Z)-3-{[3-Oxobenzofuran-2(3H)-ylidene]methyl}-4H-chromen-4-one Derivatives. Russ J Gen Chem 88, 566–572 (2018). https://doi.org/10.1134/S1070363218030283

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  • DOI: https://doi.org/10.1134/S1070363218030283

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