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Synthesis and Antifungal Activity of (±)-4-Methoxy Decanoic Acid and Its Novel Amide Derivatives

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Abstract

A simple synthetic route has been developed for fatty acid, (±)-4-methoxy decanoic acid (1), in 4 steps with 42% overall yield. The novel amide derivatives of 1 are synthesized. The in vitro antifungal activity of 1 and its novel amide derivatives 1a1f has been evaluated against different organisms. Compounds 1e, 1f exhibited antifungal activity higher than the parent compound 1 against macrophomina phaseolina, and 1a, 1d exhibited antifungal activity against sclerotium rolfsii.

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Correspondence to N. J. P. Subhashini.

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Subhashini, N.J.P., Ashok Kumar, P., Bhaskar Reddy, C. et al. Synthesis and Antifungal Activity of (±)-4-Methoxy Decanoic Acid and Its Novel Amide Derivatives. Russ J Gen Chem 88, 532–536 (2018). https://doi.org/10.1134/S1070363218030222

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  • DOI: https://doi.org/10.1134/S1070363218030222

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