Synthesis and Elucidation of Structure of Deuterated Androsta-3,5-diene-7,17-dione
The title compound was synthesized as an internal standard for the quantitative determination of Arimistane in biological samples. [2H7] Arimistane was obtained from Arimistane-d0 by alkaline H/2H exchange of the С2,4,6,8,16 protons. The location of the labels was confirmed by NMR spectroscopy. The spatial structures were studied by X-ray diffraction.
KeywordsNMR spectroscopy deuterated steroids isotopic labelling deuterium labelling [2,2,4,6,8,16,16-2H7] arimistane X-ray crystallography
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