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Russian Journal of General Chemistry

, Volume 87, Issue 12, pp 3052–3058 | Cite as

Synthesis and Elucidation of Structure of Deuterated Androsta-3,5-diene-7,17-dione

  • V. V. Abzianidze
  • T. L. Panikorovskii
  • L. S. Chisty
  • D. M. Kochura
  • D. V. Krivorotov
  • V. A. Kuznetsov
  • A. S. Radilov
Letters to the Editor

Abstract

The title compound was synthesized as an internal standard for the quantitative determination of Arimistane in biological samples. [2H7] Arimistane was obtained from Arimistane-d0 by alkaline H/2H exchange of the С2,4,6,8,16 protons. The location of the labels was confirmed by NMR spectroscopy. The spatial structures were studied by X-ray diffraction.

Keywords

NMR spectroscopy deuterated steroids isotopic labelling deuterium labelling [2,2,4,6,8,16,16-2H7] arimistane X-ray crystallography 

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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • V. V. Abzianidze
    • 1
  • T. L. Panikorovskii
    • 2
  • L. S. Chisty
    • 1
  • D. M. Kochura
    • 1
  • D. V. Krivorotov
    • 1
  • V. A. Kuznetsov
    • 1
  • A. S. Radilov
    • 1
  1. 1.Chemical Modeling Laboratory, Research Institute of Hygiene, Occupational Pathology and Human EcologyFederal Medical Biological AgencySt. PetersburgRussia
  2. 2.Department of Crystallography, Institute of Earth SciencesSt. Petersburg State UniversitySt. PetersburgRussia

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