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Synthesis and Antimicrobial Activity of Novel Substituted 4-[3-(1H-Benzimidazol-2-yl)-4-hydroxybenzyl]-2-(1H-benzimidazol-2-yl)phenol Derivatives

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Abstract

A series of novel substituted bis-benzimidazole derivatives were synthesized by reaction of 5,5′-methylenebis(2-hydroxybenzaldehyde) with various substituted o-phenylenediamines in glacial acetic acid. The structure of the newly synthesized compounds was elucidated by 1H and 13C NMR, FT-IR, and MS spectra, and their antimicrobial activity against gram positive and gram negative bacteria and antifungal activity were evaluated. The thienyl-substituted derivative showed significant activity against Bacillus licheniformis, Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia (bacteria), and Fusarium solani (fungi). The activities of the fluoro-substituted substituted derivative against some bacterial strains and of the thienyl-substituted derivative against fungi were found to be similar to those of standard drugs.

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Authors and Affiliations

  1. Department of Chemistry, University College of Science, Osmania University, Saifabad, Hyderabad, Telangana, 500004, India

    V. Anil, B. Shankar & P. Jalapathi

  2. Bioengineering and Environmental Sciences Division, Indian Institute of Chemical Technology, Hyderabad, 500007, India

    G. Bharath

Authors
  1. V. Anil
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  2. B. Shankar
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  3. G. Bharath
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  4. P. Jalapathi
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Correspondence to P. Jalapathi.

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The text was submitted by the authors in English.

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Anil, V., Shankar, B., Bharath, G. et al. Synthesis and Antimicrobial Activity of Novel Substituted 4-[3-(1H-Benzimidazol-2-yl)-4-hydroxybenzyl]-2-(1H-benzimidazol-2-yl)phenol Derivatives. Russ J Gen Chem 87, 3017–3022 (2017). https://doi.org/10.1134/S1070363217120477

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  • DOI: https://doi.org/10.1134/S1070363217120477

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