Russian Journal of General Chemistry

, Volume 87, Issue 12, pp 3006–3016 | Cite as

Efficient Synthesis and Biological Activity of Novel Indole Derivatives as VEGFR-2 Tyrosine Kinase Inhibitors

Letters to the Editor

Abstract

A series of novel indole derivatives were synthesized as potent inhibitors for the vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase. Among those, compound 10b demonstrated the highest growth inhibition rate of 66.7% against the VEGFR-2 tyrosine kinase at 10 μM which indicates that indole-benzothiazole might be the favorable structure. The binding mode of compound 10b with VEGFR-2 tyrosine kinase was evaluated by molecular docking.

Keywords

indole derivatives VEGFR-2 tyrosine kinase growth inhibition indole-benzothiazole 

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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  1. 1.College of Chemical EngineeringQingdao University of Science and TechnologyQingdaoChina

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