Russian Journal of General Chemistry

, Volume 87, Issue 12, pp 2979–2985 | Cite as

Synthesis and Cytotoxicity of 6-Substituted 1,4-Naphthoquinone Oxime Derivatives (II)

Letters to the Editor


In the present study, a series of 1,4-naphthoquinone oxime derivatives has been synthesized. The structures were confirmed by spectroscopic methods. The newly synthesized compounds were evaluated for their in vitro cytotoxicity. Among those, the compounds 8c, 8d, 8e, 12a, and 12b demonstrated potent cytotoxic activity comparable with that of the reference drug 5-Fu.


1,4-naphthoquinone oxime derivatives synthesis cytotoxic activity 


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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  1. 1.School of PharmacyShanghai Jiao Tong UniversityShanghaiChina
  2. 2.School of Pharmaceutical Sciences and ChemistryDali UniversityDaliChina

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