Russian Journal of General Chemistry

, Volume 87, Issue 12, pp 2979–2985 | Cite as

Synthesis and Cytotoxicity of 6-Substituted 1,4-Naphthoquinone Oxime Derivatives (II)

Letters to the Editor

Abstract

In the present study, a series of 1,4-naphthoquinone oxime derivatives has been synthesized. The structures were confirmed by spectroscopic methods. The newly synthesized compounds were evaluated for their in vitro cytotoxicity. Among those, the compounds 8c, 8d, 8e, 12a, and 12b demonstrated potent cytotoxic activity comparable with that of the reference drug 5-Fu.

Keywords

1,4-naphthoquinone oxime derivatives synthesis cytotoxic activity 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Chang, H.X., Chou, T.C., Savaraj, N., Liu, L.F., Yu, C., and Cheng, C.C., J. Med. Chem., 1999, vol. 42, p. 405. doi 10.1021/jm9804679CrossRefGoogle Scholar
  2. 2.
    Tandon, V.K., Maurya, H.K., Mishra, N.N., and Shukla, P.K., Eur. J. Med. Chem., 2009, vol. 44, p. 3130. doi 10.1016/j.ejmech.2009.03.006CrossRefGoogle Scholar
  3. 3.
    You, Y.J., Kim, Y., Song, G.Y., and Ahn, B.Z., Bioorg. Med. Chem. Lett., 2000, vol. 10, p. 2301. doi 10.1016/S0960-894X(00)00447-9CrossRefGoogle Scholar
  4. 4.
    Tandon, V.K., Singh, R.V., and Yadav, D.B., Bioorg. Med. Chem. Lett., 2004, vol. 14, p. 2901. doi 10.1016/j.bmcl.2004.03.047CrossRefGoogle Scholar
  5. 5.
    Huerta, S., Chilka, S., and Bonavida, B., Int. J. Oncol., 2008, vol. 33, p. 909. doi 10.3892/ijo_00000079.Google Scholar
  6. 6.
    Wang, R.B., Zhang, X., Song, H.L., Zhou, S.S., and Li, S.S., Bioorg. Med. Chem. Lett., 2014, vol. 24, p. 4304. doi 10.1016/j.bmcl.2014.07.012CrossRefGoogle Scholar
  7. 7.
    Huang, G., Zhao, H.R., Zhou, W., Dong, J.Y., Zhang, Q.J., Meng, Q.Q., Zhu, B.Q., and Li, S.S., Monatsh. Chem., 2017, vol. 148, p. 1011. doi 10.1007/s00706-016-1899-zCrossRefGoogle Scholar
  8. 8.
    Huang, G., Zhao, H.R., Meng, Q.Q., Zhou, W., Zhang, Q.J., Dong, J.Y., Cui, J.H., and Li, S.S., Chin. Chem. Lett., 2017, vol. 28, p. 1553. doi 10.1016/j.cclet.2016.10.034CrossRefGoogle Scholar
  9. 9.
    Zhao, L.M., Xie, T.P., He, Y.Q., Xu, D.F., and Li, S.S., Eur. J. Med. Chem., 2009, vol. 44, p. 1410. doi 10.1016/j.ejmech.2008.09.039CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  1. 1.School of PharmacyShanghai Jiao Tong UniversityShanghaiChina
  2. 2.School of Pharmaceutical Sciences and ChemistryDali UniversityDaliChina

Personalised recommendations