Russian Journal of General Chemistry

, Volume 87, Issue 12, pp 2961–2965 | Cite as

Synthesis of New Functionalized 1,4-Dihydroquinolines and Pyrimido[4,5-b]quinolines

  • F. Khoramdelan
  • A. Davoodnia
  • M. R. Bozorgmehr
  • M. Ebrahimi
Letters to the Editor


The reaction of N-alkylisatoic anhydrides with malononitrile in pyridine led to formation of new 2-amino-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carbonitriles. Following treatment of these compounds with an excess of aliphatic carboxylic acids in the presence of POCl3 under reflux gave novel 2,10-dialkylpyrimido[4,5-b]quinoline-4,5(3H,10H)-diones with high yields. It is probable that synthesis of the latter products proceed via the tandem intramolecular Pinner–Dimroth rearrangement. All synthesized compounds were characterized by spectral and microanalytical data.


dihydroquinoline pyrimido[4,5-b]quinoline POCl3 carboxylic acids 


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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • F. Khoramdelan
    • 1
  • A. Davoodnia
    • 1
  • M. R. Bozorgmehr
    • 1
  • M. Ebrahimi
    • 1
  1. 1.Department of Chemistry, Mashhad BranchIslamic Azad UniversityMashhadIran

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