Russian Journal of General Chemistry

, Volume 87, Issue 12, pp 2951–2960 | Cite as

Synthesis, Single Crystal X-Ray, and Anticancer Activity of Some New Thiophene and 1,3-Thiazolidine Derivatives

  • U. Fathy
  • R. S. Gouhar
  • H. M. Awad
  • H. A. Abdel-Aziz
Letters to the Editor

Abstract

New series of thiophenes 6a–6e and 1,3-thiazolidines 13a–13f and 15a–15e were synthesized starting from 2-(4-methoxybenzoyl)-3-(phenylamino)-3-thioxopropanoate 3. The reaction of 3 with 1-aryl-2-bromoethanones 4a–4e yielded thiophenes 6a–6e. The X-ray single crystal analysis data accumulated for 6c and its structural features can be extended to the analogues 6a, 6b and 6d, 6e. Treatment of 3 with ethyl 2-bromoacetate afforded 1,3-thiazolidinone 11 which upon treatment with aldehydes 12a-f or isatins 14a–4e gave 5-arylidene derivatives 13a–13f and 4-oxo-5(-2-oxoindolin)-3-ylidenes 15a–15e, respectively. The newly synthesized compounds were tested in vitro for their anti-cancer activity against two cell lines (HepG-2 and MCF-7) using MTT assay. Most of these compounds demonstrated a significant anticancer activity compared with that of doxorubicin. Isatin derivative 15a was the most potent compound against HepG-2 cancer cells whereas p-MeO substituted benzylidine 13b showed the highest anticancer activity against MCF-7 cancer cells. The fluoro substituted isatin 15d showed anticancer activity more potent than doxorubicin against both HepG-2 and MCF-7 cancer cells, respectively.

Keywords

thiophene 1,3-thiazolidine isatin single crystal X-ray diffraction anticancer 

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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • U. Fathy
    • 1
  • R. S. Gouhar
    • 2
  • H. M. Awad
    • 3
  • H. A. Abdel-Aziz
    • 1
  1. 1.Applied Organic Chemistry DepartmentNational Research CentreDokki, GizaEgypt
  2. 2.Therapeutic Chemistry DepartmentNational Research CentreDokki, GizaEgypt
  3. 3.Tanning Materials and Leather Technology DepartmentNational Research CentreDokki, GizaEgypt

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